2022 Cal Poly Mustangs football team

The 2022 Cal Poly Mustangs football team represented California Polytechnic State University as a member of the Big Sky Conference the 2022 NCAA Division I FCS football season. The Mustangs were led by third-year head coach Beau Baldwin and now played their home games at Mustang Memorial Field in San Luis Obispo, California.

Polls
On July 25, 2022, during the virtual Big Sky Kickoff, the Mustangs were predicted to finish tenth in the Big Sky by both the coaches and media.

Preseason All–Big Sky team
The Mustangs did not have any players selected to the preseason all-Big Sky team.