2023 Challenger Città di Lugano – Singles

Luca Nardi was the defending champion but chose not to defend his title.

Otto Virtanen won the title after defeating Cem İlkel 6–4, 7–6(7–5) in the final.

Seeds
• # Gijs Brouwer (first round)

• # Dominic Stricker (semifinals)

• # 🇸🇰 Norbert Gombos (first round)

• # 🇮🇹 Raúl Brancaccio (second round)

• # 🇬🇧 Liam Broady (quarterfinals)

• # 🇧🇪 Zizou Bergs (first round)

• # 🇸🇰 Lukáš Klein (first round)

• # Jelle Sels (first round)