Aminoacyl-tRNA hydrolase

The enzyme aminoacyl-tRNA hydrolase (EC 3.1.1.29) catalyzes the reaction


 * N-substituted aminoacyl-tRNA + H2O $$\rightleftharpoons$$ N-substituted amino acid + tRNA

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.