Cyclic-guanylate-specific phosphodiesterase

Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an enzyme with systematic name cyclic bis(3′→5′)diguanylate 3-guanylylhydrolase. This enzyme catalyses the following reaction:


 * cyclic di-3′,5′-guanylate + H2O $$\rightleftharpoons$$ 5′-phosphoguanylyl(3′→5′)guanosine

This enzyme requires Mg2+ or Mn2+ for activity. It is inhibited by Ca2+ and Zn2+.