Ginseng



Ginseng is the root of plants in the genus Panax, such as Korean ginseng (P. ginseng), South China ginseng (P. notoginseng), and American ginseng (P. quinquefolius), characterized by the presence of ginsenosides and gintonin. Ginseng is common in the cuisines and medicines of China and Korea.

Ginseng has been used in traditional medicine over centuries, though modern clinical research is inconclusive about its medical effectiveness. There is no substantial evidence that ginseng is effective for treating any medical condition and it has not been approved by the US Food and Drug Administration (FDA) to treat or prevent a disease or to provide a health benefit. Although ginseng is sold as a dietary supplement, inconsistent manufacturing practices for supplements have led to analyses of some ginseng products contaminated with toxic metals or unrelated filler compounds, and its excessive use may have adverse effects or untoward interactions with prescription drugs.

History
One of the first written texts covering the use of ginseng as a medicinal herb was the Shen Nong Pharmacopoeia, written in China in 196 AD. In his Compendium of Materia Medica herbal of 1596, Li Shizhen described ginseng as a "superior tonic". However, the herb was not used as a "cure-all" medicine, but more specifically as a tonic for patients with chronic illnesses and those who were convalescing.

Control over ginseng fields in China and Korea became an issue in the 16th century.

Ginseng species
Ginseng plants belong only to the genus Panax. Cultivated species include Panax ginseng (Korean ginseng), Panax notoginseng (South China ginseng), Panax pseudoginseng (Himalayan ginseng), Panax quinquefolius (American ginseng), Panax trifolius (Dwarf ginseng), and Panax vietnamensis (Vietnamese ginseng). Ginseng is found in cooler climates – Korean Peninsula, Northeast China, Russian Far East, Canada and the United States, although some species grow in warm regions – South China ginseng being native to Southwest China and Vietnam. Panax vietnamensis (Vietnamese ginseng) is the southernmost Panax species known.

Wild ginseng
Wild ginseng grows naturally in mountains and is hand-picked by gatherers known as simmani. The wild ginseng plant is almost extinct in China and endangered globally. This is due to high demand for the product in recent years, leading to the harvesting of wild plants faster than they can grow and reproduce (a wild ginseng plant can take years to reach maturity ). Wild ginseng can be processed to be red or white ginseng. Wild American ginseng has long been used by Native Americans for medicine. Since the mid-1700s, it has been harvested for international trade. Wild American ginseng can be harvested in 19 states and the Appalachian Mountains but has restrictions for exporting.

Cultivated ginseng
Cultivated ginseng is less expensive than the rarely available wild ginseng.

Cultivated ginseng is planted on mountains by humans and is allowed to grow like wild ginseng.

Ginseng processing
Ginseng seed normally does not germinate until the second spring following the harvest of berries in Autumn. They must first be subjected to a long period of storage in a moist medium with a warm/cold treatment, a process known as stratification.

Fresh ginseng
Fresh ginseng, also called "green ginseng", is non-dried raw product. Its use is limited by availability.

White ginseng
White ginseng is peeled and dried ginseng. White ginseng is fresh ginseng which has been dried without being heated. It is peeled and dried to reduce the water content to 12% or less. Drying in the sun bleaches the root to a yellowish-white color.

Red ginseng
Red ginseng is steamed and dried ginseng, which has reddish color. Red ginseng is less vulnerable to decay than white ginseng. It is ginseng that has been peeled, heated through steaming at standard boiling temperatures of 100 °C, and then dried or sun-dried. It is frequently marinated in an herbal brew which results in the root becoming extremely brittle.

Production
Commercial ginseng is sold in over 35 countries, with China as the largest consumer. In 2013, global sales of ginseng exceeded $2 billion, of which half was produced by South Korea. In the early 21st century, 99% of the world's 80,000 tons of ginseng was produced in just four countries: China (44,749 tons), South Korea (27,480 tons), Canada (6,486 tons), and the United States (1,054 tons). All ginseng produced in South Korea is Korean ginseng (P. ginseng), while ginseng produced in China includes P. ginseng and South China ginseng (P. notoginseng). Ginseng produced in Canada and the United States is mostly American ginseng (P. quinquefolius).

Uses
Ginseng may be included in energy drinks or herbal teas in small amounts or sold as a dietary supplement.

Food or beverage
The root is most often available in dried form, either whole or sliced. In Korean cuisine, ginseng is used in various banchan (side dishes) and guk (soups), as well as tea and alcoholic beverages. Ginseng-infused tea and liquor, known as insam cha (literally "ginseng tea") and insam-ju ("ginseng liquor") is consumed. Ginseng leaves are also used to prepare foods and beverages. Leaves are used to prepare Asian soups, steamed with chicken or combined with ginger, dates, and pork, or are eaten fresh.

Traditional medicine and phytochemicals
Although ginseng has been used in traditional medicine for centuries, there is no conclusive modern research that it has biological effects. Preliminary clinical research indicates there are no confirmed effects on memory, fatigue, menopause symptoms, and insulin response in people with mild diabetes. A 2021 review indicated that ginseng had "only trivial effects on erectile function or satisfaction with intercourse compared to placebo". , there is no good evidence to indicate that taking ginseng causes any improvement of health or lowers the risk of any disease.

Although the roots are used in traditional Chinese medicine, the leaves and stems contain larger quantities of the phytochemicals than the roots, and are easier to harvest. The constituents include steroid saponins known as ginsenosides, but the effects of these ginseng compounds have not been studied with high-quality clinical research as of 2021, and therefore remain unknown.

FDA warning letters
As of 2019, the United States FDA and Federal Trade Commission have issued numerous warning letters to manufacturers of ginseng dietary supplements for making false claims of health or anti-disease benefits, stating that the "products are not generally recognized as safe and effective for the referenced uses" and are illegal as unauthorized "new drugs" under federal law.

Safety and side effects
Ginseng supplements are not subjected to the same pre-market approval process in the US by the Food and Drug Administration (FDA) as pharmaceutical drugs. FDA mandates that manufacturers must ensure the safety of their ginseng supplements before marketing, without the necessity to substantiate the safety and efficacy of these supplements in a pre-market scenario. Ginseng supplements can be complex, often containing multiple constituents. It is not uncommon to observe discrepancies between the ingredients listed on the product label and the actual components or their quantities present in the supplement. While manufacturers can employ independent organizations to authenticate the quality of a product or its ingredients, such verification does not equate to a certification of the product's safety or effectiveness. These independent quality checks primarily focus on the integrity of the product in terms of its composition and do not extend to safety evaluations or purported clinical efficacy.

Ginseng contains steroidal saponins known as ginsenosides, polyacetylenes, polysaccharides, peptidoglycans, and polyphenols, among diverse other phytochemicals, but the effects of these compounds in humans are unknown.

Ginseng generally has a good safety profile and the incidence of adverse effects is minor when used over the short term. The FDA has classified ginseng as "generally recognized as safe" (GRAS), indicating its general tolerability in adult populations.

The risk of interactions between ginseng and prescription medications is believed to be low, but ginseng may have adverse effects when used with blood thinners. Ginseng interacts with certain blood thinner medications, such as warfarin, leading to decreased blood levels of these drugs. Ginseng can also potentiate the effects of sedative medications. Concerns exist when ginseng is used over a longer term, potentially causing side effects such as skin rashes, headaches, insomnia, and digestive problems. The long-term use of ginseng may result in nervousness, anxiety, diarrhea, confusion, depression, or feelings of depersonalization, nausea, and fluctuations in blood pressure (including hypertension). There have been reports of gynecomastia and breast pain associated with ginseng use. Other side effects include breast pain and vaginal bleeding. As of 2023, there is a lack of data regarding the safety and efficacy of ginseng in lactating mothers and infants. Given its potential estrogenic activity and the absence of safety data during lactation, ginseng is not recommended for use during breastfeeding. Ginseng also has adverse drug reactions with phenelzine, and a potential interaction has been reported with imatinib, resulting in hepatotoxicity, and with lamotrigine.

Overdose
The common ginsengs (P. ginseng and P. quinquefolia) are generally considered to be relatively safe even in large amounts. One of the most common and characteristic symptoms of an acute overdose of P. ginseng is bleeding. Symptoms of mild overdose may include dry mouth and lips, excitation, fidgeting, irritability, tremor, palpitations, blurred vision, headache, insomnia, increased body temperature, increased blood pressure, edema, decreased appetite, dizziness, itching, eczema, early morning diarrhea, bleeding, and fatigue.

Symptoms of severe overdose with P. ginseng may include nausea, vomiting, irritability, restlessness, urinary and bowel incontinence, fever, increased blood pressure, increased respiration, decreased sensitivity and reaction to light, decreased heart rate, cyanotic (blue) facial complexion, red facial complexion, seizures, convulsions, and delirium.

Terminology and etymology
The English word "ginseng" comes from the Teochew Chinese jîn-sim (where this transliteration is in Pe̍h-ōe-jī). The first character (pinyin rén;  or ) means "person" and the second character   means "plant root" in a forked shape.

The Korean loanword insam comes from the cultivated ginseng, which is less expensive than wild ginseng.

The botanical genus name Panax, meaning "all-healing" in Greek, shares the same origin as "panacea" and was applied to this genus because Carl Linnaeus was aware of its wide use in Chinese medicine as a muscle relaxant.

Other plants sometimes called ginseng
True ginseng plants belong only to the genus Panax. Several other plants are sometimes referred to as ginseng, but they are from a different genus or even family. Siberian ginseng is in the same family, but not genus, as true ginseng. The active compounds in Siberian ginseng are eleutherosides, not ginsenosides. Instead of a fleshy root, Siberian ginseng has a woody root.
 * Angelica sinensis (female ginseng, dong quai)
 * Codonopsis pilosula (poor man's ginseng, dangshen)
 * Eleutherococcus senticosus (Siberian ginseng)
 * Gynostemma pentaphyllum (five-leaf ginseng, jiaogulan)
 * Kaempferia parviflora (Thai ginseng, krachai dum)
 * Lepidium meyenii (Peruvian ginseng, maca)
 * Oplopanax horridus (Alaskan ginseng)
 * Pfaffia paniculata (Brazilian ginseng, suma)
 * Pseudostellaria heterophylla (Prince ginseng)
 * Schisandra chinensis (five-flavoured berry)
 * Trichopus zeylanicus (Kerala ginseng)
 * Withania somnifera (Indian ginseng, ashwagandha)
 * Eurycoma longifolia (Malaysian ginseng, tongkat ali)