Gliquidone

Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehringer Ingelheim (Germany).

Contraindications

 * Allergy to sulfonylureas or sulfonamides
 * Diabetes mellitus type 1
 * Diabetic ketoacidosis
 * Patients that underwent removal of the pancreas
 * Acute porphyria
 * Severe liver disease accompanying with liver insufficiency
 * Several conditions (e.g., infectious diseases or major surgical intervention), when insulin administration is required
 * Pregnancy or breastfeeding

Pharmacokinetics
Gliquidone is fully metabolized by the liver. Its metabolites are excreted virtually completely with bile (even with long-term administration), thus allowing the use of medication in diabetic patients with kidney disease and diabetic nephropathy.