Inositol-polyphosphate 5-phosphatase

The enzyme inositol-polyphosphate 5-phosphatase, systematic name 1 D -myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses the following reactions:


 * (1) D -myo-inositol 1,4,5-trisphosphate + H2O $$\rightleftharpoons$$ myo-inositol 1,4-bisphosphate + phosphate
 * (2) 1 D -myo-inositol 1,3,4,5-tetrakisphosphate + H2O $$\rightleftharpoons$$ 1 D -myo-inositol 1,3,4-trisphosphate + phosphate

Ten mammalian isoforms are known.

Other names of this enzyme include type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D -myo-inositol 1,4,5-triphosphate 5-phosphatase, D -myo-inositol 1,4,5-trisphosphate 5-phosphatase, L -myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphatase D -myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase.