Pelubiprofen

Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis.

Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia, among other countries.

Research
Pelubiprofen is being studied for use in combination with eperisone.

Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied.

Synthesis
Pelubiprofen can be prepared by the reaction of 1-(1-piperidino)cyclohexene (1) with ethyl 2-(4-formylphenyl)propanoate (2).