Phosphoethanolamine/phosphocholine phosphatase

Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75, PHOSPHO1, 3X11A; systematic name phosphoethanolamine phosphohydrolase) is an enzyme highly expressed in mineralizing cells. This enzyme is implicated in bone and cartilage formation and catalyses the following chemical reactions:


 * (1) O-phosphoethanolamine + H2O $$\rightleftharpoons$$ ethanolamine + phosphate
 * (2) phosphocholine + H2O $$\rightleftharpoons$$ choline + phosphate

The enzyme is a member of the haloacid dehalogenase superfamily. Like other members of this superfamily it requires a metal ion for catalysis, which is usually Mg2+, it is also active in the presence of Co2+ or Mn2+ but exhibits a lower specific activity with these metal ions.