Phosphogluconate dehydratase

The enzyme phosphogluconate dehydratase catalyzes the chemical reaction


 * 6-phospho- D -gluconate $$\rightleftharpoons$$ 2-dehydro-3-deoxy-6-phospho- D -gluconate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho- D -gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho- D -gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho- D gluconate hydro-lyase. This enzyme participates in the Entner–Doudoroff pathway.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.