Pseudouridylate synthase

The enzyme pseudouridylate synthase catalyzes the chemical reaction


 * uracil + D -ribose 5-phosphate $$\rightleftharpoons$$ pseudouridine 5′-phosphate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is uracil hydro-lyase (adding D -ribose 5-phosphate pseudouridine-5′-phosphate-forming). Other names in common use include pseudouridylic acid synthetase, pseudouridine monophosphate synthetase, 5-ribosyluracil 5-phosphate synthetase, pseudouridylate synthetase, upsilonUMP synthetase, and uracil hydro-lyase (adding D -ribose 5-phosphate). This enzyme participates in pyrimidine metabolism.

Structural studies
As of late 2007, 22 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , and.