Setastine

Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.

Pharmacodynamics
Setastine acts as a highly selective H1 receptor antagonist. It has no anticholinergic, antiadrenergic, or antiserotonergic effects.

Pharmacokinetics
Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.