Talk:Mitochondrial disease

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Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 04:18, 17 January 2022 (UTC)

Category: Mitochondrial diseases?
This article could be the basis for a Category:Mitochondrial diseases --apers0n 08:29, 12 October 2006 (UTC)

Causes
Mutations to mitochondrial DNA occur frequently, due to the lack of the error checking capability that nuclear DNA has.

Don't you mean, due to a lack of error checking that Mitochondrial DNA has? Nuclear DNA checks itself very well indeed. But it does not have anything to do with checking the Mitochondrial DNA. —The preceding unsigned comment was added by Tourskin (talk • contribs) 19:55, 28 April 2007 (UTC).

i think the original author means that the mitochondrial check capabilities lack the sophistication that exists in the nucleius — Preceding unsigned comment added by 203.185.131.218 (talk) 04:04, 6 December 2013 (UTC)

Mitochondrial DNA, however, is strictly inherited from the mother and each mitochondrial organelle typically contains between 2 and 10 mtDNA copies.

A just-published study in November 2018 refutes this: http://www.pnas.org/content/early/2018/11/21/1810946115

I do not know enough about the subject to edit this competently, but just thought I would bring this new study to others' attention, in order possibly to edit that paragraph.BillDeeUS (talk) 17:22, 4 December 2018 (UTC)

Treatments:
The mention of pyruvate as a potential treatment for mitochondrial disease. Appears to suggest it is a cure all! Perhaps greater specificity on what it might help cure would be a good idea.

As a general comment for this artical, it is all very non-specific but treats the diseases as if they are all really similar. —Preceding unsigned comment added by 163.1.159.98 (talk) 11:26, 14 February 2009 (UTC)

The section headed Treatments and proposed genetic manipulations ends by referencing three videos but the link was wrong (it pointed to just one of them). My edit links to the external page from which all three videos can be viewed. Imaginif (talk) 12:47, 1 February 2015 (UTC)

Energetics of mitochondrial deactivation
I can only assume this was written by someone who has English as a secondary language, and has a very poor grasp of sentence structure and paragraph formatting. i have tried adding the first two paragraphs, but i honestly think it needs a total rewrite, as i can barley understand what the author is trying to say, something i don't have the time or the expertise for.

I actually suspect this section should be spit into several others

Research Suggestion
The drug hydroxyurea has found a new use in the treatment of Sickle Cell disease, turning on the fetal hemoglobin gene. If there are some mitochondrial diseases that occur when a functional fetal gene has been turned off in favor of a defective adult gene coding a mitochondria component then maybe hydroxyurea could prove useful. It is not known exactly how hydroxyurea works, but it is very toxic, Nitric Oxide is thought to play a part. So, if hydroxyurea would prove useful then maybe organic nitrates used in angina might be a safer substitute. I have hardly any depth in molecular biology, so this suggestion is just a wild guess for researchers to consider. 71.127.28.55 (talk) 05:33, 9 June 2010 (UTC)

Darwin & Mito
This is highly speculative that Darwin suffered from a mito disease. Very few people claim this, John hayman being the most prominent recent claimant, and his thesis remains questionable at the moment. — Preceding unsigned comment added by 121.219.119.240 (talk) 13:25, 21 September 2012 (UTC)

It's all in your head!
is this disease oft misdiagnosed? we have a ridiculous case in boston right now where doctors at one hospital have legally seized a child, claiming that the parents and prior set of doctors were abusing her by treating her for mito, which she, quote, "does not have".

we're not talking phony surgeons set up in a motel; these are prominent doctors at two of the top hospitals here. we the public are all scratching our heads.

i was expecting to find some "controversy" section in this article, like with autism or certain other diseases where the medical community is split. 209.172.25.27 (talk) 20:38, 25 February 2014 (UTC)

Justina Pelletier
It's currently highly controversial whether this person is afflicted with this illness. I the article should reflect this controversy.

2601:0:5B00:4F5:685E:EAF4:409:6041 (talk) 02:51, 20 June 2014 (UTC)
 * I've removed her name from the list, along with those of two other people without Wikipedia pages, whose notability seems to stem mainly from having been diagnosed with a mitochondrial disease. 86.164.164.123 (talk) 12:45, 23 September 2014 (UTC)

Article suggests mitochondria in humans are much more widespread than they are
This article appears to be a bit misleading as it says mitochondria are "..found in every cell of the human body except red blood cells." However, red blood cells are the most common types of cell in the body? Maybe a bit like saying something takes place every day except Mondays to Saturdays. In other words, does not take place every day, just takes place on Sundays. Perhaps not exactly the same as, for all I know, all non-red blood cells added together may be more than the number of red blood cells, therefore may be the exclusion of the greatest minority and still be a majority of cells have mitochondria or maybe it is a minority and most cells don't have them as red blood cells are the most common according to the article on red blood cells.

Whilst this article does contain a link to the red blood cells article, it cannot be assumed that all readers would click through and the phraseology used in this article on mitochondria disease is a bit misleading to talk of every cell except... when the exclusion is it seems of the most common type of cell that doesn't have them.

This is quite a significant exclusion but the significance is not made clear and for all I know it could well exclude 99% of cells and mitochondria only be in a tiny minority of cells, therefore quite wrong to say "every cell except" and for the exception potentially to be so widespread. That would be more like mitochondria are fairly rare as they are only in cells if they aren't red blood cells that are the most common types of cell. aspaa (talk) 13:33, 04 January 2024 (UTC)