Vetispiradiene synthase

Vetispiradiene synthase (EC 4.2.3.21) is an enzyme from Egyptian henbane that catalyzes the following chemical reaction:


 * (2E,6E)-farnesyl diphosphate $$\rightleftharpoons$$ vetispiradiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming). Other names in common use include vetispiradiene-forming farnesyl pyrophosphate cyclase, pemnaspirodiene synthase, HVS, and vetispiradiene cyclase. This enzyme participates in terpenoid biosynthesis.