1980–81 Cheshire County Football League

The 1980–81 Cheshire County Football League was the 57th in the history of the Cheshire County League, a football competition in England. Teams were divided into two divisions.

Division One
The division featured two new teams, both promoted from last season's Division Two:
 * Prescot Town (1st), changed their name to Prescot Cables
 * Kirkby Town (3rd)

Division Two
The division featured five new teams:
 * 2 relegated from last seasons Division One:
 * Rhyl (19th)
 * Radcliffe Borough (20th)
 * 3 joined the division:
 * Leyland Motors, from Lancashire Combination
 * Atherton Laburnum Rovers, from Bolton Combination
 * Salford, merger of Anson Villa and Salford Amateurs