2021–22 Real Betis season

The 2021–22 season was the 114th season in the existence of Real Betis and the club's seventh consecutive season in the top flight of Spanish football. In addition to the domestic league, Real Betis participated in this season's editions of the Copa del Rey and the UEFA Europa League.

First-team squad
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Matches
The league fixtures were announced on 30 June 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Knockout round play-offs
The knockout round play-offs draw was held on 13 December 2021.

Round of 16
The draw for the round of 16 was held on 25 February 2022.

Appearances and goals

 * Last updated 20 May 2022.

! colspan=14 style=background:#dcdcdc; text-align:center|Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center|Defenders

! colspan=14 style=background:#dcdcdc; text-align:center|Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center|Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players who have made an appearance or had a squad number this season but have left the club either permanently or on loan


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