2022 Santa Cruz Challenger II – Singles

Francisco Cerúndolo was the defending champion but chose not to defend his title.

Paul Jubb won the title after defeating Juan Pablo Varillas 6–3, 7–6(7–5) in the final.

Seeds
• # 🇧🇴 Hugo Dellien (withdrew)

• # Pablo Cuevas (semifinals)

• # 🇵🇪 Juan Pablo Varillas (final)

• # 🇦🇷 Tomás Martín Etcheverry (withdrew)

• # Tomás Barrios Vera (quarterfinals)

• # 🇦🇷 Camilo Ugo Carabelli (withdrew)

• # 🇦🇷 Facundo Mena (quarterfinals)

• # Jesper de Jong (second round, retired)