2023 Advantage Cars Prague Open – Men's singles

Pedro Cachin was the defending champion but chose not to defend his title.

Dominic Stricker won the title after defeating Sebastian Ofner 7–6(9–7), 6–3 in the final.

Seeds
• # 🇷🇸 Filip Krajinović (semifinals)

• # 🇲🇩 Radu Albot (first round)

• # 🇦🇷 Juan Manuel Cerúndolo (first round)

• # 🇫🇷 Hugo Gaston (first round)

• # 🇭🇺 Zsombor Piros (first round, retired)

• # 🇨🇿 Tomáš Macháč (second round)

• # Dominic Stricker (champion)

• # 🇦🇹 Sebastian Ofner (final)