2023 San Luis Open Challenger – Men's singles

Antoine Bellier was the defending champion but lost in the first round to Alexis Galarneau.

Tomás Barrios Vera won the title after defeating Dominik Koepfer 7–6(8–6), 7–5 in the final.

Seeds
• # 🇦🇺 James Duckworth (first round)

• # Antoine Bellier (first round)

• # Tomás Barrios Vera (champion)

• # 🇦🇷 Renzo Olivo (second round, retired)

• # 🇦🇷 Facundo Mena (first round)

• # 🇯🇵 Rio Noguchi (first round)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇩🇴 Nick Hardt (first round)