16-Methylene-17α-hydroxyprogesterone acetate

16-Methylene-17α-hydroxyprogesterone acetate is a progestin of the 17α-hydroxyprogesterone group which was never marketed. Given orally, it shows about 2.5-fold the progestogenic activity of parenteral progesterone in animal bioassays. It is a parent compound of the following clinically used progestins:


 * Chlormethenmadinone acetate (6-chloro-16-methylene-17α-hydroxy-Δ6-progesterone acetate)
 * Melengestrol acetate (6-methyl-16-methylene-17α-hydroxy-Δ6-progesterone acetate)
 * Methenmadinone acetate (16-methylene-17α-hydroxy-Δ6-progesterone acetate)
 * Segesterone acetate (16-methylene-17α-hydroxy-19-norprogesterone acetate)