Flugestone acetate

Flugestone acetate (FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.

Veterinary
FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.

Chemistry
FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. It is the C17α acetate ester of flugestone.

History
FGA was developed and marketed by G.D. Searle & Company in the 1960s.

Generic names
Flugestone acetate is the generic name of the drug and its INN and BANM, while flurogestone acetate is its USAN. Flugestone is the BAN and DCIT of the unesterified free alcohol form. FGA is also known by its developmental code names NSC-65411 and SC-9880.

Brand names
FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.

Availability
FGA is marketed for veterinary use in Australia, France, Ireland, Israel, Italy, the Netherlands, South Africa, and the United Kingdom.