Haloprogesterone

Haloprogesterone, sold under the brand name Prohalone, is a progestin medication which was previously marketed by Ayerst but is now no longer available.

Chemistry
Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of progesterone. It is specifically a derivative of 17α-bromoprogesterone and is similar structurally to medrogestone (6-dehydro-6,17α-dimethylprogesterone), medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.

Synthesis
Chemical syntheses of haloprogesterone have been published.

History
Haloprogesterone was synthesized in 1960 and was introduced for medical use by 1961.

Generic names
Haloprogesterone is the generic name of the drug and its INN and USAN.

Brand names
Haloprogesterone was marketed under the brand name Prohalone.