1978 Nicholls State Colonels football team

The 1978 Nicholls State Colonels football team represented Nicholls State University as a member of the Gulf South Conference (GSC) the 1978 NCAA Division II football season. Led by fifth-year head coach Bill Clements, the Colonels compiled an overall record of 5–6 with a conference mark of 5–2, tying for third place in the GSC. Nicholls State played home games at John L. Guidry Stadium in Thibodaux, Louisiana.