1985–86 UC Sampdoria season

U.C. Sampdoria fell short of repeating its successful 1984–85 season, ending up in 12th position in the league. It did almost defend its cup title successfully, but despite a 2–1 victory in the first leg, it lost to Roma in the return leg. Sampdoria's European adventure did not live up to expectations, it not even reaching the quarter-finals of the Cup Winners' Cup.

Topscorers

 * 🇮🇹 Roberto Mancini 6
 * 🇮🇹 Gianluca Vialli 6
 * 🇮🇹 Giuseppe Lorenzo 3
 * Graeme Souness 3

Coppa Italia
First Round

Eightfinals

Quarterfinals

Semifinals