2021–22 UC Sampdoria season

The 2021–22 season was the 76th season in the existence of U.C. Sampdoria and the club's 10th consecutive season in the top flight of Italian football. In addition to the domestic league, Sampdoria participated in this season's edition of the Coppa Italia.

Matches
The league fixtures were announced on 14 July 2021.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season