1999 Italian Open – Men's singles

Gustavo Kuerten defeated Patrick Rafter in the final, 6–4, 7–5, 7–6(8–6) to win the men's singles tennis title at the 1999 Italian Open.

Marcelo Ríos was the defending champion, but lost in the first round to David Prinosil.

Seeds
• #🇷🇺 Yevgeny Kafelnikov (third round)

• #🇺🇸 Pete Sampras (second round)

• #🇪🇸 Álex Corretja (semifinals)

• #🇦🇺 Patrick Rafter (final)

• # Richard Krajicek (second round)

• #🇪🇸 Carlos Moyà (third round)

• #🇬🇧 Tim Henman (third round)

• # Marcelo Ríos (first round)

• #🇦🇺 Mark Philippoussis (first round)

• #🇸🇰 Karol Kučera (quarterfinals)

• #🇺🇸 Todd Martin (withdrew)

• #🇬🇧 Greg Rusedski (second round)

• #🇪🇸 Álbert Costa (first round)

• #🇺🇸 Andre Agassi (third round)

• #🇪🇸 Félix Mantilla (semifinals)

• #🇧🇷 Gustavo Kuerten (champion)