1999 French Open – Men's singles

Andre Agassi defeated Andriy Medvedev in the final, 1–6, 2–6, 6–4, 6–3, 6–4 to win the men's singles tennis title at the 1999 French Open. It was his first French Open title and fourth major title overall, becoming the second man in the Open Era (after Rod Laver) to complete the career Grand Slam, and the first to do so across three surfaces. He also completed the career Super Slam (having previously won Olympic gold and the year-end championships), the only men's singles player to do so.

Carlos Moyá was the defending champion, but lost in the fourth round to Agassi.

This tournament was also the first major in which future 20-time major champion and world No. 1 Roger Federer and future French Open champion Gaston Gaudio competed in the main draw; they lost to Patrick Rafter and Àlex Corretja in the first round and third round, respectively.

Seeds
• 🇷🇺 Yevgeny Kafelnikov (second round)

• 🇺🇸 Pete Sampras (second round)

• 🇦🇺 Patrick Rafter (third round)

• 🇪🇸 Carlos Moyá (fourth round)

• Richard Krajicek (second round)

• 🇪🇸 Àlex Corretja (quarterfinals)

• 🇬🇧 Tim Henman (third round)

• 🇧🇷 Gustavo Kuerten (quarterfinals)

•  Marcelo Ríos (quarterfinals)

• 🇦🇺 Mark Philippoussis (first round)

• 🇸🇰 Karol Kučera (first round)

• 🇬🇧 Greg Rusedski (fourth round)

• 🇺🇸 Andre Agassi (champion)

• 🇪🇸 Félix Mantilla (fourth round)

•  Goran Ivanišević (first round)

• 🇸🇪 Thomas Enqvist (second round)