2007 Western & Southern Financial Group Women's Open – Singles

Vera Zvonareva was the defending champion, but had to withdraw before the tournament began due to a right wrist injury.

Anna Chakvetadze won the title, defeating Akiko Morigami 6–1, 6–3 in the final.

Seeds
• # Anna Chakvetadze (champion)

• # 🇨🇭 Patty Schnyder (quarterfinals)

• # 🇮🇳 Sania Mirza (semifinals)

• # Meilen Tu (withdrew due to left wrist injury)

• # 🇯🇵 Aiko Nakamura (first round)

• # Elena Vesnina (quarterfinals, retired due to a right shoulder injury)

• # 🇯🇵 Akiko Morigami (final)

• # 🇫🇷 Séverine Brémond (withdrew due to illness)

• # Jill Craybas (second round)