2007 US Open – Mixed doubles

Martina Navratilova and Bob Bryan were the defending champions, but Navratilova retired from the sport at the end of 2006. Bryan partnered Tatiana Golovin, and lost in the second round to Sania Mirza and Mahesh Bhupathi.

Victoria Azarenka and Max Mirnyi won the title, defeating Meghann Shaughnessy and Leander Paes in the final 6–4, 7–6(8–6). This was Azarenka's first Grand Slam title; she would later win 2 Grand Slam singles titles and reach No. 1 in the world.

Seeds
• # 🇺🇸 Lisa Raymond / 🇷🇸 Nenad Zimonjić (first round)

• # 🇦🇺 Alicia Molik / 🇺🇸 Mike Bryan (second round)

• # 🇨🇳 Yan Zi / Mark Knowles (semifinals)

• # 🇮🇹 Mara Santangelo / 🇦🇺 Paul Hanley (first round)

• # 🇨🇿 Květa Peschke / 🇨🇿 Martin Damm (second round)

• # Cara Black / 🇵🇱 Marcin Matkowski (first round)

• # 🇷🇺 Elena Likhovtseva / 🇨🇦 Daniel Nestor (first round)

• # Chuang Chia-jung / 🇮🇱 Jonathan Erlich (second round)