2008 Western & Southern Financial Group Women's Open – Singles

Anna Chakvetadze was the defending champion, but chose not to participate that year.

Nadia Petrova won in the final 6–2, 6–1, against Nathalie Dechy.

Seeds
• # 🇫🇷 Marion Bartoli (first round, retired due to an abdominal pain)

• # 🇷🇺 Nadia Petrova (champion)

• # 🇷🇺 Maria Kirilenko (semifinals)

• # Katarina Srebotnik (second round)

• # 🇫🇷 Amélie Mauresmo (semifinals)

• # 🇨🇦 Aleksandra Wozniak (quarterfinals)

• # 🇷🇺 Ekaterina Makarova (first round)

• # 🇦🇹 Tamira Paszek (first round)