2021–22 PSV Eindhoven season

The 2021–22 season was the 109th season in the existence of PSV Eindhoven and the club's 66th consecutive season in the top flight of Dutch football. In addition to the domestic league, PSV Eindhoven participated in this season's editions of the KNVB Cup, the Johan Cruyff Shield, the UEFA Champions League, the UEFA Europa League and the UEFA Europa Conference League.

Matches
The league fixtures were announced on 11 June 2021.

Second qualifying round
The draw for the second qualifying round was held on 16 June 2021.

Third qualifying round
The draw for the third qualifying round was held on 19 July 2021.

Play-off round
The draw for the play-off round was held on 2 August 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Knockout round play-offs
The Knockout round play-offs draw was held on 13 December 2021.

Round of 16
The round of 16 draw was held on 25 February 2022.

Quarter-finals
The draw for the quarter-finals was held on 18 March 2022.

Appearances and goals
! colspan="18" style="background:#dcdcdc; text-align:center"| Goalkeepers

! colspan="18" style="background:#dcdcdc; text-align:center"| Defenders

! colspan="18" style="background:#dcdcdc; text-align:center"| Midfielders

! colspan="18" style="background:#dcdcdc; text-align:center"| Forwards

! colspan="18" style="background:#dcdcdc; text-align:center"| Players transferred out during the season


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