2021–22 Rice Owls women's basketball team

The 2021–22 Rice Owls women's basketball team represented Rice University during the 2021–22 NCAA Division I women's basketball season. The team was led by first-year head coach Lindsay Edmonds, and played their home games at the Tudor Fieldhouse in Houston, Texas as a member of Conference USA.

Schedule and results
!colspan=12 style=|Non-conference regular season

!colspan=12 style=|CUSA regular season

!colspan=9 style=| Conference USA Tournament