2021–22 Slovak Cup

The 2021–22 Slovak Cup was the 53rd edition of the competition.

Slovan Bratislava were the defending champions, defeating Žilina in the 2021 final.

Slovan Bratislava managed to advance to the final again, but were defeated by their rivals Spartak Trnava.

Spartak Trnava earned automatic qualification for the UEFA Europa Conference League second qualifying round.

Format
The Slovak Cup is played as a knockout tournament. All matches that end up as a draw after 90 minutes are decided by penalty shoot-outs. All rounds are played as one-off matches except the semi-finals, which are played over two legs.

Preliminary round
!colspan="3" align="center"| 18 July 2021

!colspan="3" align="center"| 24 July 2021

!colspan="3" align="center"| 25 July 2021

!colspan="3" align="center"| 28 July 2021

!colspan="3" align="center"| 29 July 2021


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First round
!colspan="3" align="center"| 30 July 2021

!colspan="3" align="center"| 31 July 2021

!colspan="3" align="center"| 1 August 2021

!colspan="3" align="center"| 3 August 2021

!colspan="3" align="center"| 4 August 2021

!colspan="3" align="center"| 5 August 2021

!colspan="3" align="center"| 11 August 2021


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Second round
!colspan="3" align="center"| 18 August 2021

!colspan="3" align="center"| 24 August 2021

!colspan="3" align="center"| 25 August 2021

!colspan="3" align="center"| 1 September 2021

!colspan="3" align="center"| 4 September 2021

!colspan="3" align="center"| 22 September 2021


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Third round
!colspan="3" align="center"| 14 September 2021

!colspan="3" align="center"| 15 September 2021

!colspan="3" align="center"| 21 September 2021

!colspan="3" align="center"| 22 September 2021

!colspan="3" align="center"| 28 September 2021

!colspan="3" align="center"| 29 September 2021

!colspan="3" align="center"| 6 October 2021

!colspan="3" align="center"| 9 October 2021


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Fourth round
The draw for the fourth round was held on 7 October 2021.

!colspan="3" align="center"| 19 October 2021

!colspan="3" align="center"| 20 October 2021

!colspan="3" align="center"| 26 October 2021

!colspan="3" align="center"| 27 October 2021

!colspan="3" align="center"| 2 November 2021

!colspan="3" align="center"| 3 November 2021

!colspan="3" align="center"| 10 November 2021

!colspan="3" align="center"| 21 November 2021

!colspan="3" align="center"| 12 February 2022

!colspan="3" align="center"| 15 February 2022


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Round of 16
The draw for the round of 16 was held on 2 December 2021.

!colspan="3" align="center"| 1 March 2022

!colspan="3" align="center"| 2 March 2022

!colspan="3" align="center"| 9 March 2022


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Quarter-finals
The draw for the quarter-finals was held on 3 March 2022.

Semi-finals
The draw for the semi-finals took place on 18 March 2022.