2021 Columbus Challenger

The 2021 Columbus Challenger was a professional challenger level tennis tournament played on indoor hard courts. It was the tenth edition of the men's tournament which was part of the 2021 ATP Challenger Tour and the first edition of the women's event, that was part of 2021 WTA 125K series. It took place in Columbus, United States between 20 and 26 September 2021.

Men's singles

 * 🇺🇸 Stefan Kozlov def. 🇦🇺 Max Purcell 4–6, 6–2, 6–4.

Women's singles

 * 🇪🇸 Nuria Párrizas Díaz def. 🇨🇳 Wang Xinyu, 7–6(7–2), 6–3

Men's doubles

 * 🇺🇸 Stefan Kozlov / 🇨🇦 Peter Polansky def. 🇺🇸 Andrew Lutschaunig / 🇯🇵 James Trotter 7–5, 7–6(7–5).

Women's doubles

 * 🇨🇳 Wang Xinyu / 🇨🇳 Zheng Saisai def. Dalila Jakupović / 🇪🇸 Nuria Párrizas Díaz, 6–1, 6–1

Seeds

 * 1 Rankings are as of September 13, 2021.

Other entrants
The following players received entry into the singles main draw as wildcards:
 * 🇺🇸 Cannon Kingsley
 * 🇺🇸 James Tracy
 * 🇨🇿 Matěj Vocel

The following players received entry into the singles main draw as alternates:
 * 🇺🇸 Nick Chappell
 * 🇦🇺 Dayne Kelly

The following players received entry into the singles main draw from the qualifying draw:
 * Gijs Brouwer
 * 🇰🇷 Chung Yun-seong
 * 🇺🇸 Evan King
 * 🇺🇸 Aleksandar Kovacevic

The following players received entry as lucky losers:
 * 🇨🇦 Alexis Galarneau
 * 🇯🇵 Shintaro Mochizuki

Seeds

 * 1 Rankings are as of September 13, 2021.

Other entrants
The following players received entry into the singles main draw as wildcards:
 * 🇫🇷 Elsa Jacquemot
 * 🇺🇸 Elvina Kalieva
 * 🇺🇸 Katrina Scott
 * 🇺🇸 Peyton Stearns

The following player was accepted directly into the main draw using a protected or a special ranking:
 * Liang En-shuo

The following players received entry into the singles main draw from the qualifying draw:
 * 🇺🇸 Louisa Chirico
 * 🇺🇸 Alexa Glatch
 * 🇦🇺 Priscilla Hon
 * 🇺🇸 Danielle Lao

The following player received entry into the singles main draw as a lucky loser:
 * Dalila Jakupović

Withdrawals

 * Before the tournament
 * 🇨🇿 Marie Bouzková → replaced by 🇧🇷 Beatriz Haddad Maia
 * 🇺🇸 Christina McHale → replaced by 🇯🇵 Kurumi Nara
 * 🇺🇸 Caty McNally → replaced by 🇺🇸 Katie Volynets
 * 🇺🇸 Grace Min → replaced by 🇺🇸 Francesca Di Lorenzo
 * 🇷🇺 Anna Kalinskaya → replaced by Dalila Jakupović
 * 🇺🇦 Kateryna Kozlova → replaced by 🇺🇸 Hailey Baptiste
 * 🇺🇸 Claire Liu → replaced by 🇺🇸 Asia Muhammad
 * 🇬🇧 Emma Raducanu → replaced by 🇨🇦 Rebecca Marino
 * Donna Vekić → replaced by 🇺🇸 Jamie Loeb

Seeds

 * Rankings are as of September 13, 2021

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇫🇷 Luna Dormet / 🇪🇸 Lucía Marzal Martínez
 * 🇫🇷 Elsa Jacquemot / 🇺🇸 Eleana Yu