2021 I.ČLTK Prague Open – Men's doubles

The men's doubles of the 2021 I.ČLTK Prague Open tournament was played on clay in Prague, Czech Republic.

Pierre-Hugues Herbert and Arthur Rinderknech were the defending champions but chose not to compete this year.

Marc Polmans and Sergiy Stakhovsky won the title after defeating Ivan and Matej Sabanov 6–3, 6–4 in the final.

Seeds
• # 🇺🇦 Denys Molchanov / 🇰🇿 Aleksandr Nedovyesov (quarterfinals)

• # 🇻🇪 Luis David Martínez / 🇪🇸 David Vega Hernández (quarterfinals)

• # Ivan Sabanov / Matej Sabanov (final)

• # 🇩🇪 Andre Begemann / 🇩🇪 Daniel Masur (first round)