2021 Southeastern Louisiana Lions football team

The 2021 Southeastern Louisiana Lions football team represented Southeastern Louisiana University as a member of the Southland Conference during the 2021 NCAA Division I FCS football season. The Lions were led by fourth-year head coach Frank Scelfo and played their home games at Strawberry Stadium.

Preseason poll
The Southland Conference released their preseason poll in July 2021. The Lions were picked to finish first in the conference. In addition, sixteen Lions were chosen to the Preseason All-Southland Team.

Preseason All–Southland Teams
Offense

1st Team
 * Cole Kelley – Quarterback, SR
 * CJ Turner – Wide Receiver, RS-JR
 * Jalen Bell – Offensive Lineman, JR
 * Mateo Rengifo – Kicker, SO
 * Austin Dunlap – Punter, SO

2nd Team
 * Damien Dawson – Tight End/Halfback, RS-SR
 * Austin Mitchell – Wide Receiver, RS-SR
 * Ethan McMullan – Offensive Lineman, SR
 * Rendon Miles-Character – Offensive Lineman, SR
 * Drew Jones – Offensive Lineman, SR

Defense

1st Team
 * Darrius Harry – Defensive Lineman, RS-FR
 * Alexis Ramos – Linebacker, SR
 * Ferlando Jordan – Defensive Back, RS-JR
 * Donnell Ward-McGee – Defensive Back, JR

2nd Team
 * Herman Christophe – Linebacker, SO
 * Jack Henderson – Defensive Back, FR