2021 Northwestern State Demons football team

The 2021 Northwestern State Demons football team represented Northwestern State University as a member of the Southland Conference during the 2021 NCAA Division I FCS football season. Led by fourth-year head coach Brad Laird, the Demons compiled an overall record of 3–8 with a mark of 3–5 in conference play, tying for fourth place in the Southland. Northwestern State played home games at Harry Turpin Stadium in Natchitoches, Louisiana.

Preseason poll
The Southland Conference released their preseason poll in July 2021. The Demons were picked to finish fifth in the conference. In addition, nine Demons were chosen to the Preseason All-Southland Team.

Preseason All–Southland Teams
Offense

1st Team
 * Scooter Adams – Running Back, JR

2nd Team
 * Khalil Corbett-Canada – Offensive Lineman, SR
 * Jakob Sell – Offensive Lineman, JR
 * Scotty Roblow – Punter, RS-SO

Defense

1st Team
 * Jomard Valsin – Linebacker, JR

2nd Team
 * Ja'Quay Pough – Linebacker, SR
 * P. J. Herrington – Defensive Back, JR
 * William Hooper – Defensive Back, JR
 * Donovan Duvernay – Kick Returner, SR