Wikipedia talk:WikiProject Molecular Biology/Archive 1

Proposal

 * Discussion initiated at WT:WikiProject Biology

There are many small Wikiprojects within biology (compares to unified WP:Physics or WP:Medicine) with large overlaps in scope. Their efforts could be more efficient if joined into larger projects.
 * Problem

A Possible unification of some of the sub-cellular wikiprojects with large scope overlaps, including: Initial draft structure: T.Shafee(Evo &#38; Evo)talk 02:17, 26 May 2019 (UTC)
 * Proposal
 * WP:MCB
 * WP:BIOP
 * WP:GEN
 * WP:COMBIO
 * Formatting using WP:X templates (as WP:MED, WP:EVO and WP:WPWIR
 * Unified talkpage
 * Unified main landing page, but maintain distinctiveness of taskforces

A possible Science/STEM User Group

 * This was posted in the various WikiProjects just before they were merged as taskforces, so I thought would be useful to repost here.

There's a discussion about a possible User Group for STEM over at Meta:Talk:STEM_Wiki_User_Group. The idea would be to help coordinate, collaborate and network cross-subject, cross-wiki and cross-language to share experience and resources that may be valuable to the relevant wikiprojects. Current discussion includes preferred scope and structure. T.Shafee(Evo &#38; Evo)talk 12:22, 16 June 2019 (UTC)

Discussion at Draft talk:Horizontal transfer of mitochondria
You are invited to join the discussion at Draft talk:Horizontal transfer of mitochondria. Worldbruce (talk) 14:47, 24 June 2019 (UTC)

Our logo on the cover of Laboratory Equipment
Just an FYI, our Zika logo above is the cover image of the May/June issue of Laboratory Equipment, which has an article on the intersection of art and science. Congratulations to artist David Goodsell for scoring a cover page. -- 18:39, 26 June 2019 (UTC)
 * I have always loved his work. I was given his book "The Machinery of Life" a few years back and I can absolutely recommend it as an excellent gift. T.Shafee(Evo &#38; Evo)talk 00:49, 27 June 2019 (UTC)

Would you kindly help me with this image

 * This was posted in WikiProject MCB just before it was merged as a taskforce, so I thought would be useful to repost here.

Hello everyone, i am the author of the DNA replication image give or take i made this image arround 2007, i have been asked to modify it to incorporate all the comments and corrections made on the discussion page plus someone left the following request on the Graphics lab on commons:
 * Pol epsilon should be on the leading strand and attached to the helicase (which should have a ring structure). Pol delta should be on the lagging strand. Pol delta might have some role in leading strand replication (still debated to which extend), but is mostly responsible for lagging strand replication. See also File talk:DNA replication en.svg --大诺史

Now I am an illustrator and by no means expert in this subject so i would really appreciate if someone with the appropriate knowledge could have a look on this Sketch. it isnt yet on its final form but the elements are in the relative position i am hoping them to have (all marked with ? would need some reassuring). also there is like a ton of questions i would really want to have answer if that is ok:
 * I have been told that the polymerase that works on the leading strand is attached to the helicase. if so, where do the SSBs (single stranded binding proteins) connect on that side of the fork? also i have seen other diagrams with this polymerase hugging the lagging strand instead sso whicone would be correct?
 * i made the sliding clamp on the polymerase seem part of the same body, i am aware it is a completely different enzyme is just i thought it would show they both work together and also gives the drawing some directionality which seems to be important in this subject. is this ok?
 * i am very confused about which polymerase is what greek letter of pol. on the sketch i have made my best guess but i still not sure which is which. Also would it be a problem if a place several polymerases working on different sections of the lagging strand? at the moment the same primase, and polymerase must go round and round backwards to do the job.
 * on the last image i was asked at least once a month to change the 3'5' notations on the diagram. i have made a little color hook on the primers to show where the 3' end of it would be, and made a image section to explain here is where the polymerase attaches to start working. would this be helpfull or do you think it will make things more confusing?
 * is it practical to add the Telomerase in the diagram? i am not even sure if it would attach there, would you find it more useful or should i leave it out?
 * because of space resstrains i placed the RNAse at the same spot than the DNA polymerase that repairs the gap. is this understandable or would they need their own gap?
 * In many images i have fished out online (excluding those based on my own image) i have found often that enzymes are much bigger than what i have show, and i dont mind that becouse more than scale i am more interested in showing function, but it does worry when i see images like this one where the single strand make strange loops.. is there anything about this i should be aware of?

if you would be so kind to answer my questions i could at least have some degree of confidence in remaking the image in a better more accurate state. 大诺史 was kind to offer this article as reference. I look forward to your feedback. and thank you for your time -LadyofHats (talk) 18:58, 5 June 2019 (UTC)


 * I'm terribly sorry that I am unable to answer most of your questions. I am certainly not an expert on this, and I imagine that you haven't been answered just because people don't know how to help you, not because they haven't seen your post or don't care. What I can say is that I don't think it is necessary for you to include telomerase. In my limited experience, I don't remember it being included in many general diagrams like yours. It would be cool to have it, but I wouldn't think it necessary.
 * I am sorry to bother you, but I can literally not think of a better person to help User:LadyofHats or direct her to an expert on this topic. Do you think you could be of some help here? Prometheus720 (talk) 13:15, 17 June 2019 (UTC)

and First, a couple of important caveats. I am primarily a geneticist rather than a biochemist and I'm happy to be corrected by any of my more biochemically oriented colleagues who may be reading this. It appears to me that you are trying to illustrate eukaryotic DNA replication (at least that's the nomenclature you are using). That's fine, and I've geared my answer with that in mind, but be aware that there are significant difference between eukaryotic and prokaryotic replication (as well as commonalities). Having said that, my answers to your queries (in the order you asked them) are:
 * 1) Pol ε (epsilon) is the primary leading strand polymerase and Pol δ (delta) is the primary lagging strand polymerase. There is some argument about whether each of them “moonlights” in other contexts, but for a baseline model those designations are fine.  A complex of proteins comprised of Cdc45-MCM–GINS (called CMG for short) makes up the eukaryotic replicative helicase.  There is very good data showing that Pol ε physically interacts with the helicase (https://doi.org/10.1073/pnas.1700530114).  SSBs are likely indiscriminate and will bind to any available single-stranded DNA.  Since Pol ε physically interacts with the helicase, which will be positioned at the replication fork, there probably isn’t a need to depict it on the leading strand.
 * 2) Sliding clamps are accessory proteins that increase the efficiency (processivity to be precise) of replication.  It is loaded onto the primer-template duplex and then forms physical interactions with its associated polymerase.  As such, I would show it as a distinct element that is physically contacts the polymerase.
 * 3) Pol ε (epsilon) is the leading strand polymerase. Pol δ (delta) is the primary lagging strand polymerase. Pol α (alpha) functions on both the leading and lagging strands to synthesize the first short (roughly 20 nucleotide) stretch of DNA from the RNA primers, then hands off to more processive polymerases (like epsilon or delta), it also fill in the gaps left after primers are removed (see below). Primase is an RNA polymerase that synthesizes the RNA primers used by the DNA polymerases to initiate synthesis.  I’m not sure what you mean by the same polymerase going round and round.  It is true that the lagging strand is discontinuous – i.e. it proceeds away from the replication fork, synthesizes until it hits the next upstream okazaki fragment and then stops, the fork meanwhile has progressed to reveal more ssDNA and another lagging strand polymerase is loaded and synthesizes another segment (over and over again).
 * 4) Being clear about the polarity of the nucleic acids (5' and 3') is very important.  This is something that learners are generally confused by when trying to tackle the topic and it turns out that once you understand the polarity issue a lot of the rest of the mechanics of replication falls into place.  Yes, I think the inset box would help folks.  However, I think I would avoid the word “attaches” (this may be confused with some kind of chemical linkage).  Instead I would say that the polymerase catalyzes addition of nucleotides at the 3' hydroxyl (OH).
 * 5) End replication (telomere replication) is a specialized mechanism that involves a whole host of other players.  I do not recommend trying to incorporate it into this diagram.
 * 6) In your sketch you have RNAse (presumably to remove the RNA primers created by Primase) but this is probably incorrect.  Currently it is thought that Pol δ displaces the 5' end of the RNA primer it encounters to create ssRNA flap that is then cleaved by a structure-specific endonuclease called FEN1 (note, removal of primers works by a different mechanism in prokaryotes – in bacteria the lagging strand polymerase, called DNA polymerase I has a 5' to 3' exonuclease).
 * 7) I’m sure you know much more about illustrating than I do, but as a consumer of illustrations I generally think of two kinds.  The first are highly technical depictions of structural studies (like x-ray crystallography) that attempt to accurately display both size and position of the constituent units (bases, amino acids, atoms etc).  The second are conceptual models that attempt to depict a set of relationships (physical interactions, or functional partnerships), sometimes as a snapshot in a process (like replication).  It seems to me that you’re going for the latter, so I wouldn’t worry too much about relative scales (within reason).
 * 8) The looping model you point to is arguing for a polymerase dimer mechanism.  To my knowledge this is a model in the prokaryotic replication field – and for that you will have to find help from someone who knows far more about prokaryotic biochemistry than I do.

I hope that's of some small help. Good luck! Gcopenhaver1 (talk) 18:41, 17 June 2019 (UTC)Gcopenhaver1


 * and i can not thank you enough for your answers. i will get working with what i got so far and show you the image for review when it is done. Thankyou once more -LadyofHats (talk) 09:15, 18 June 2019 (UTC)

Please have a look at this Final draft and let me know if it is ok or in your opinion needs any changes -LadyofHats (talk) 10:31, 28 June 2019 (UTC)
 * , RNAse is usually spelled with the last two letters lowercase. You also missed an e in exonuclease in that area. Your blurb on topoisomerase should say "unwind." Not all the blurbs are capitalized at the beginning. Pol alpha needs to be spelled with a ph. In the info box, you could add "group" at the end of the blurb, which would likely make it fit perfectly. For ligase, I would clarify which ligase it is. Also, your image makes it look like ligase is "retwisting" the double strand back to its normal state. Your old image left a little room to show that the ligase is joining the two strands, but that the twisting is not due to anything the ligase is doing directly. Could you move the ligases back a few nucleotides to show that ligase does not twist the DNA? I would also say "rejoins strands" or "connects strands" or something like that. "Seals strand" implies that the entire DNA molecule which is being created can be called a strand. That's something that confuses some people. My last gripe is that there are not the same number of nucleotides on the left as on the right. I know that is really hard to show in an image like this, but DNA replication is semi-conservative and we try to hammer that into biology students. It would probably be a lot of work to kink that right molecule around to make it the same as the left side, so if you can't do that, then at least put some kind of note at the bottom.
 * I'm sorry if I sound really critical--I just want to be careful. I actually think that it's a great diagram and I really like some of the concepts. The box is cool, and so are the arrows on the polymerases. That is a good feature. I think that the more well-researched diagrams there are out there of DNA replication, especially in the public domain, the better. Thanks for doing this! Prometheus720 (talk) 17:00, 28 June 2019 (UTC)
 * I'm sorry if I sound really critical--I just want to be careful. I actually think that it's a great diagram and I really like some of the concepts. The box is cool, and so are the arrows on the polymerases. That is a good feature. I think that the more well-researched diagrams there are out there of DNA replication, especially in the public domain, the better. Thanks for doing this! Prometheus720 (talk) 17:00, 28 June 2019 (UTC)


 * you shouldnt worry to be critical since at this stage of the image creation is the right time to find all posible mistakes. i am out of the city but on Tuesday when i am back i will edit the image and upload it to commons. once again thankyou for all your imput. has been very helpfull-LadyofHats (talk) 23:52, 28 June 2019 (UTC)

final version is here -LadyofHats (talk) 21:33, 2 July 2019 (UTC) , do you have any further comments? I may have missed something here. Prometheus720 (talk) 21:50, 2 July 2019 (UTC)
 * , That's looking better! I did notice that the top Pol a text is touching the right strand, and the box text is escaping the box. The only other thing I would say is that alpha is usually spelled as alpha in English, and that the bottom pol a says "fill" and I would change that to "fills." I really like the grayed-out end of the right strand. That is a very good compromise, and I noticed you moved the ligases back as well. I think it's just about ready! Great work!
 * one of the reasons i like to outline text in my images is because svg tends to move it around, tried to fix it as much as i could-LadyofHats (talk) 23:31, 2 July 2019 (UTC)

Topoisomerases
I just noticed that Topoisomerase and DNA Topoisomerase should probably be merged (discussion here). Would anyone be interested in looking through to see if anything is salvageable? T.Shafee(Evo &#38; Evo)talk 11:13, 7 July 2019 (UTC)

Uploading more David Goodsell images
One of the achievements of WP:Biophysics back in 2014 was persuading David Goodsell and the PDB to release a whole load of images under CC-BY. I've finished uploading all the released molecular landscape images. Plenty of the Molecule of the Month images are already uploaded, but there are significant gaps (I've renamed them per their series number). If anyone would be happy to help upload some of the missing ones (and the new ones as they come out) it'd be greatly appreciated! T.Shafee(Evo &#38; Evo)talk 01:32, 14 July 2019 (UTC)

I love it!
I would say that somewhere in the projects and partnerships area we should consider giving some information on other Wikiprojects. If we don't want to do the whole structure of WP:BIOL and its daughter projects, we should at least get WP:BIOL, WP:Micro, WP:Physio, and WP:MED as those projects would likely be of most interest to participants here.

As for discussions, is there a way to hook in the talk pages for those projects until we actually merge them?

And then, as for metrics, I'm thinking that we need to see if we can include something about how those are measured. Maybe a link to the rubric and some information about how we run our assessments (in the future of course). I'd be happy to scrounge that up if you think that sounds good. Also noting the absence of WP:BIOP. Are we going to fold that into the other taskforces, or did you just not include it for some other reason?

Finally, in metrics, I have been bothered for some time about COMBIO's lack of expanded article classes and just chucking everything into NA. Now it also bothers me that the charts are uneven. To me, it is a good thing to be able to keep track of redirects and category pages and so on. What are your thoughts on having a conversation about expanding that? Prometheus720 (talk) 15:58, 28 May 2019 (UTC)


 * Currently I've placed all projects' "Version 1.0 Editorial Team" tables in the Metrics section. There's a pretty large overlap in them (e.g. wp:GEN's table has >90% overlap with wp:MCB). It might even be better to consolidate to one? T.Shafee(Evo &#38; Evo)talk 13:23, 5 June 2019 (UTC)
 * I've also asked whether Article alerts can be added to a module over at User_talk:Isarra. T.Shafee(Evo &#38; Evo)talk 13:30, 5 June 2019 (UTC)

Name
The current draft name is WikiProject Genetic, Molecular and Cellular Biology. I'd be a fan of a shorter name, since even this long name omits developmental biology, microbiology, biochemistry, biophysics, bioinformatics, computational biology etc. My suggestion would be something like WikiProject Molecular Biology or similar, but I'm flexible and happy to wait for more people to contribute to a consensus. T.Shafee(Evo &#38; Evo)talk 07:47, 29 May 2019 (UTC)
 * I'm not against the current name. However, I'm not against changing it either. I have toyed around with Cellular and Molecular Biology (CMB) but unfortunately, WP:CMB is already registered as a shortcut. Your idea of Molecular Biology has a shortcut choice of WP:MOL or WP:MOLBIO, of which I would much prefer the latter. So it seems a better choice than trying to register CMB for us. I'd support your name, although I also would like to hear more ideas before we run with it. Prometheus720 (talk) 01:39, 30 May 2019 (UTC)
 * That WP:CMB is already registered shouldn’t be much of a problem. It isn’t used normally on a single page with the 4 pages where it is used being this discussion, two tables with all three letter shortcuts and the destination page. The page is also tagged as historical so it’s very unlikely it will see more use in the future. Trialpears (talk) 13:28, 5 June 2019 (UTC)
 * A look through Q15884967 also gives an indication of the range of WikiProject names that are used across languages. T.Shafee(Evo &#38; Evo)talk 01:49, 6 June 2019 (UTC)
 * +1 for WP:Molecular Biology. Adrian J. Hunter(talk•contribs) 08:07, 11 June 2019 (UTC)
 * Another vote for Molecular Biology! Thanks for all the work on this! Ajpolino (talk) 20:04, 13 June 2019 (UTC)

The old WP:WikiProject_Molecular_Biology was a redirect to WP:MCB. A discussion to delete it to make space for this wikiproject is here. T.Shafee(Evo &#38; Evo)talk 10:32, 15 June 2019 (UTC)
 * Molecular Biology

Merging process and taskforces
I've asked about the technical/practical aspects of merging wikiprojects over at the WikiProject_Council talkpage. T.Shafee(Evo &#38; Evo)talk 13:25, 5 June 2019 (UTC)
 * Based on this process of converting wikiprojects to taskforces:
 * Confirmed the plan to merge at the relevant wikiproject talk pages. T.Shafee(Evo &#38; Evo)talk 11:20, 15 June 2019 (UTC)
 * Requested a set of pagemoves at Wikipedia:Requested_moves/Technical_requests. T.Shafee(Evo &#38; Evo)talk 11:20, 15 June 2019 (UTC)
 * Requested a bot at Wikipedia:Bot_requests to convert the relevant wikiproject talkpage templates into taskforce tags of a new . T.Shafee(Evo &#38; Evo)talk 11:46, 15 June 2019 (UTC)

Setting up Discussions
I've done a bit of digging and it seems that Discussions on other WPX projects are populated by User:Reports bot, and that one must somehow subscribe to this bot in order to receive Discussion links. The bot (as well as the Requests system) is maintained by User:Harej who is semi-inactive.

I took a look at his contribs to see if he has done any setup before, and found this diff in which it seems he input parameters for a Wikiproject in order to set it up for various WPX things. I believe that this is where we need to go. Due to WP:OWN I don't think it should be a problem for us to just go in and input parameters for GMCB/BIOL/any other projects we redesign--however, after a first glance I'm not entirely sure I understand everything on that page.

Does this seem correct to both of you? We may have to try emailing Harej soon. Prometheus720 (talk) 17:43, 9 June 2019 (UTC)


 * I think that looks right thing to copy. My advice is try it because it can always be undone if it breaks something! will have to give any further advice on anything more technical than that, since it's well beyond my coding skills! T.Shafee(Evo &#38; Evo)talk 12:24, 10 June 2019 (UTC)


 * Turns out that page is protected and I would have to submit an edit request, so I'm trying to work everything out in advance. I'm having some trouble with one of the parameters though. There is a service to send an automated list of missing articles using Wikidata. I looked at WP:WOMSCI for reference, and I really like what their list does--it spits out articles which have entries on other Wikipedias but not on enwiki. That is exactly what I would want for WP:BIOL.
 * To do this, you have to input a SPARQL query. I was previously unfamiliar with SPARQL but it's basically just a system to get data out of a database by making simple statements. However, their query doesn't mention anything at all about languages--it seems to just define Wikidata objects that would be of interest to their project, namely women scientists. I don't understand if the code of Reports bot does the languages part for us or what. I'm at a bit of a standstill at the moment. Do you know anything about SPARQL that might help me figure this out?
 * Finally, I'm taking a look at the metrics section. If you want to set up metrics for GMCB you could probably set it to the default of looking at the talk page banner, but for WP:BIOL we don't use the banner for most of the articles under our scope. For the purpose of metrics I'd probably want to use categories or another SPARQL search to return a list of articles under our subprojects as well. So I have to figure that out as well--somehow I need to represent the larger footprint of WP:BIOL across its subprojects. I don't think I'll have this done for a day or two, but I will let you know when I do so that I can help you set up GMCB to your liking. Hopefully I'll be a pro by then! In the meantime I will continue working on other modules.Prometheus720 (talk) 06:53, 11 June 2019 (UTC)
 * Sadly I'm also a SPARQL beginner. However Wikidata:Request_a_query may be useful. It'd be similarly useful at some point to generate a list of in-scope articles that are FA in other languages but not English. T.Shafee(Evo &#38; Evo)talk 07:06, 11 June 2019 (UTC)
 * That's a fabulous idea! It has also occurred to me that even if we can't use SPARQL to generate these lists automatically, we might be able to set up something with categories using PetScan and just run the search again every so often. I designed a draft recurring schedule for maintenance like that for WP:BIOL, so that would just be another thing to do monthly or so. I guess I'll give up and try and request a query. Thanks for that link! Prometheus720 (talk) 16:05, 11 June 2019 (UTC)
 * Well, that's a bit scary, but I'm really glad you guys seem to have figured it out... yeah, I'm helpful. >.> -— Isarra ༆ 18:50, 19 June 2019 (UTC)

Participants list is down
I just tried adding myself as a member and the GUI hangs. It's been loading for several minutes. I'll be working on the same module for WP:BIOL soon enough so I may be of some help then. Just thought I would mention it now, though, in case it's an easy fix. Prometheus720 (talk) 18:51, 11 June 2019 (UTC)
 * . So the template is, which creates be calling the link:

https://en.wikipedia.org/w/index.php?action=edit &preload=Template:WikiProjectCard/Preload &editintro=Template:WikiProjectCard/Editintro &summary=Joining+WikiProject &title=Special:MyPage/WikiProjectCards/WikiProject_Molecular_Biology &create=Join+WikiProject
 * I'll have to pass this question to . The equivalent for Women in red works fine, so there must be something I've not yet set up for this page. T.Shafee(Evo &#38; Evo)talk 00:01, 12 June 2019 (UTC)
 * To lighten load on Isarra, Also pinging and  as FormWizard gurus who might be able to spot a quick fix. T.Shafee(Evo &#38; Evo)talk 10:44, 14 June 2019 (UTC)
 * I think I see what the problem is here. In order for the Join function to work, FormWizard needs instructions for what to show in the form. It's not finding any where it expects it to, so the GUI is hanging. Template:WPX member box doesn't generate that, unfortunately, and these instructions are typically housed in the MediaWiki: namespace. For example, WP:WikiProject Women in Technology uses MediaWiki:Gadget-formWizard/WikiProject Women in Technology/Join. I'm going to copy over some instructions from another source to MediaWiki:Gadget-formWizard/WikiProject Molecular Biology/Join and make some changes to the text, which should address the problem. I JethroBT (WMF) (talk) 17:22, 14 June 2019 (UTC)
 * Dang. While creating MediaWiki:Gadget-formWizard/WikiProject Molecular Biology/Join was necessary, it wasn't sufficient to make the join function work properly, and the form still isn't loading for some reason. might also be able to figure out why, since these sorts of pages were set up as a part of WP:WikiProject X. I JethroBT (WMF) (talk) 17:43, 14 June 2019 (UTC)
 * I tried changing the content model to match that of the WiR config file - maybe that'll help? Because it's all I could think of. -— Isarra ༆ 18:43, 19 June 2019 (UTC)
 * Champion! It seems to be working for me now (for the record, this is the diff that seemed to fix it). Would you be able to summarise the page you greated in the documentation of  so that it can be replicated if needed? I'll also work on adding the documentation of steps that I took in using the template/module. T.Shafee(Evo &#38; Evo)talk 03:29, 20 June 2019 (UTC)

There is an additional problem. I used the join feature like a month ago, and I just had to add my card manually. It was my understanding that User:Reports_bot is supposed to do this. I didn't sign us up because I wasn't entirely sure how to do so properly and Harej is very hard to get a hold of. I see that he actually made an edit fairly recently and I will try once again to contact him. If we don't get a response I'm going to go ahead and sign up for reports bot.

As a separate issue, we don't have any members. I am considering collecting have collected a full, organized list of members for the various taskforces and am now considering entering a mass message request to notify all of them and ask them to join the new and improved project. Do you feel ready for that, or would you rather wait? Prometheus720 (talk) 15:27, 6 July 2019 (UTC)

Setting up Stats via WP 1.0 bot/talk page banner stuff
I was editing WP:BIOL's statistics section to have a collapsible bit that showed a table of small stat tables--actually I copied the code from the Metrics section you built here and tweaked it a bit. Thanks for making that!

In the process I found out that WikiProject Ecoregions does not have stats via WP 1.0 bot in order to even generate a table. We will have to deal with that here as well, sooner or later. So I'm gonna link you to the guide at Version 1.0 Editorial Team/Using the bot. It will not be totally possible to get this working until we have a talk page template here, but it should not be too hard to basically just copy off of similar projects and then tweak to make sure it supports what we do and do not want to support.

One thing that has bothered me about COMBIO for example is that it doesn't support article classes like file, template, redirect, etc. Everything just goes into NA and in a big project like this will be, that is not ok. So I would wish for something more like MCB's, which has pretty much whatever we would need at first glance.

In the mean time I will be setting this up for WP:Ecoregions since they already have most of the stuff they need for the bot to run. If you want I can help set it up here when we are ready, or you can get started yourself. Up to you/your schedule. See ya! Prometheus720 (talk) 20:06, 13 June 2019 (UTC)
 * If you manage to get it up and running for WikiProject Ecoregions, I'd love your assistance in implementing it here. I think the simplest method will be using Version 1.0 Editorial Team/MCB articles by quality statistics as the starting point and moving/renaming it and redirecting pages towards it. T.Shafee(Evo &#38; Evo)talk 07:03, 15 June 2019 (UTC)


 * So I was very confused as to why the table would not work when I called it. Turns out there have been some typos when it was set up. Version_1.0_Editorial_Team/Ecoregion_articles_by_quality_statistics needed to be moved to say Ecoregions with an s at the end. That page also had a typo calling ANOTHER page, which I could fix. I really do not like that the WP 1.0 bot has to edit so many pages on Wiki to do the same thing. It feels like a very poor way of handling this. So it turned out that all the machinery was already there, I just had to unstick some gears.


 * However, I do feel like after doing all this I am prepared to set things up for MOLBIO apart from template creation. I do not, at present, know how to do that. Once we have the template, we can go ahead and start tagging our project pages with it, and then I will set up all the stuff we need for WP 1.0 bot. We can also look for a way to transfer all of the MCB tags to MOLBIO tags. If I understand correctly, you want MOLBIO to actually replace MCB, and then you want to put GEN, BIOP, and COMBIO underneath it? So MCB articles should not be in a taskforce at all, they should be our "main" articles, right? In that case, instead of making a new template, what if we just take the MCB talk page template, rename/move it, and all that? Prometheus720 (talk) 18:01, 15 June 2019 (UTC)
 * I'm not certain, so I've added that to my query over at Wikipedia:Bot_requests. T.Shafee(Evo &#38; Evo)talk 12:52, 16 June 2019 (UTC)
 * , Looks like the request isn't going anywhere for now. Is there anything we can do on our end? I've been going through some of the unassessed articles just to keep everything a bit neater for the move. Should we just go ahead and make a new template? If we can't get a bot request in, it's my understanding that AutoWikiBrowser with the Kingbotk plugin will do page assessment tasks. For the smaller projects, BIOP and CS, we could likely use AWB. Perhaps that would be enough for testing/proof of concept? I could try to apply for permissions. Prometheus720 (talk) 15:12, 6 July 2019 (UTC)

Projects Finally Moved
Wow, that was something to wake up to! I'm concerned about a lot of broken links and so on. What do we need to do in order to take care of that? Here is the What Links Here on the old redirect. I also notice that WikiProject_Molecular_Biology/Molecular_and_Cell_Biology did not do so well in the move. The page history doesn't show me what it used to look like, either. What can we do about that?

I haven't looked at BIOP yet but I bet it's in similar shape, only with less stuff in it.

Finally, why didn't you move GEN yet? I know people asked us to wait on COMBIO. Did people ask that for GEN as well? Or are we just doing this bit by bit? Prometheus720 (talk) 16:45, 15 June 2019 (UTC)


 * The requested moves should have gone through the system now. I think WP:Gen should now be moved to a taskforce subpage. T.Shafee(Evo &#38; Evo)talk 02:24, 16 June 2019 (UTC)

Taskforce links/tabs
We'll want some links to the active (and inactive) taskforces somewhere on the main WP:MOLBIO page, as well as the talkpages on the this page. I'll format up some simple templates asap and we can work out where is the best place to put them (as well as how to best consolidate the archive links, proably something like ). After that we can take our time in any formatting changes that would be useful for the taskforces and decide whether the Biophysics taskforce should be marked as inactive. T.Shafee(Evo &#38; Evo)talk 13:02, 16 June 2019 (UTC)
 * I've created initial talkpage headers and  to start to clarify the relationships and what should be posted where. Some posts have still been made to multiple taskforce talkpages that might be more sensible to post just this page. The headers should format nicely at any width and I've also added WP:WPMP to the list. Will do a bit of simplification and cleanup on the WP main pages in bits and pieces over the coming weeks. T.Shafee(Evo &#38; Evo)talk 12:37, 6 July 2019 (UTC)
 * , Great stuff! And btw, regarding the u --> re fix you did on another page, I'm using Enterprisey's Reply Link script, and that's how it tags people. Anyway, good eye finding WP:WPMP! I'm sorry I have been a bit absent lately--this wikiproject work has been a bit too technical and I felt a bit burned out. But I'm ready to start helping out again! Let me know if you need anything at all! Prometheus720 (talk) 14:58, 6 July 2019 (UTC)
 * No problem at all. The next technical steps will be simplifying the various taskforce main pages, whilst still retaining the important information. Having said that, it's easy to get over-focused on the technical aspects - there's still things like outreach and actual content creation! T.Shafee(Evo &#38; Evo)talk 00:32, 7 July 2019 (UTC)
 * New templates for taskforce pages . Still need to list the taskforces on each of the pages (ideally clear, without being obtrusive, or taking up too much space). T.Shafee(Evo &#38; Evo)talk 12:19, 14 July 2019 (UTC)

Your input appreciated
Hi all,

I would appreciate your input in this strange case: Wikipedia_talk:Copyright_problems.

--Steven Fruitsmaak (Reply) 20:03, 20 July 2019 (UTC)


 * Thanks - I've left a suggestion. T.Shafee(Evo &#38; Evo)talk 23:40, 20 July 2019 (UTC)

Discussion at Talk:De novo gene birth
(RfC link) There's a discussion here about best applying relative due weights to a molbio topic with multiple competing hypotheses that could benefit from the input of some experienced wikipedians. T.Shafee(Evo &#38; Evo)talk 01:52, 24 July 2019 (UTC)

Merger discussion for CD64_(biology)

 * Moved over from WT:MCB T.Shafee(Evo &#38; Evo)talk 23:15, 19 August 2019 (UTC)

An article that you have been involved in editing&mdash;CD64_(biology)&mdash;has been proposed for merging with another article. If you are interested, please participate in the merger discussion. Thank you. SCIdude (talk) 14:44, 19 August 2019 (UTC)

Kuo-Chen Chou et al
There seems to be a whole group of articles on Kuo-Chen Chou and his findings that are highly promotional, hard to understand, almost exclusively reference his own papers, and have been created/expanded by a few editors whose sole editing focus seems to be this topic. I've poked around a bit, but I don't really understand the topic. Does anyone have more familiarity with the topic? Can't tell if these articles just need to be cleaned up, or if some merging/redirecting/deletion might be in order for some of these. Articles I've noticed so far: Any insight would be helpful. Thanks! Ajpolino (talk) 20:49, 21 August 2019 (UTC)
 * Kuo-Chen Chou
 * Gordon Life Science Institute (previously speedied as copyvio, just recreated which is what brought this to my attention; looks like it has been speedied again. Leaving link in case it comes back)
 * 5-step rules
 * Chou's invariance theorem
 * Pseudo K-tuple nucleotide composition
 * Pseudo amino acid composition
 * Draft:The 5-step rules for proteome or genome analysis (created but then moved to draft)
 * Wenxiang diagram
 * Low-frequency collective motion in proteins and DNA
 * Chou's distorted key theory for peptide drugs
 * My initial thoughts:
 * Kuo-Chen Chou is certainly notable and the 'recognition' section is probably fair. The 'Career' section probably needs a bit of copyediting and cleanup.
 * Sufficiently notable: PseAAC and PseKNCr aee rasonably well known (though I couldn't say whether ithey're eing over-emphasised over equivalent methods).
 * Non-notable:: More of an issue are the following likely correct but extremely niche articles and a strong over-reliance on only citing the work of Chou himself: Low-frequency collective motion in proteins and DNA (also very poorly explained), Chou's distorted key theory for peptide drugs, Chou's invariance theorem, Chou’s 5-step rule (also over-promotional).
 * On the edge: Wenxiang diagram should probably be merged with helical wheel 2-dimensional α-helical diagrams or similar.
 * T.Shafee(Evo &#38; Evo)talk 12:53, 22 August 2019 (UTC)
 * Just a note, a handful of mostly single-purpose accounts has made all of these articles. The currently active one was blocked a few hours ago for being exclusively promotional. Also thanks E&E for your thoughts above! Ajpolino (talk) 14:52, 22 August 2019 (UTC)

Portal:Biological warfare
FYI Portal:Biological warfare is being considered for deletion. --Nessie (talk) 13:43, 28 August 2019 (UTC)

Dispute on interpretation of 2019 paper on genetics of homosexuality
My own amateurish reading of the paper makes it sound like it contradicts itself. Is the variance in same-sex behavior explained by the genetic differences 8-25% or <1%?

[https://en.wikipedia.org/wiki/Talk:Biology_and_sexual_orientation#Adding_lines_to_cromosome_section_latest_science_magazine_studies. Discussion here].

Paper here. Note especially the 3 paragraphs between figures 2 and 3.

-Crossroads- (talk) 19:09, 1 September 2019 (UTC)

9th ISCB Wikipedia Competition: entries open now!
Hi everyone,

It's my pleasure to announce that entries for the 9th ISCB Wikipedia Competition are open now!

The competition is run annually by the International Society for Computational Biology (ISCB) and the Computational Biology taskforce of WikiProject Molecular Biology. A key component of the ISCB's mission to further the scientific understanding of living systems through computation is to communicate this knowledge to the public at large. Wikipedia has become an important way to communicate all types of science to the public and the ISCB aims to further its mission by increasing the quality of Wikipedia coverage of computational biology, and by improving accessibility to this information via Wikipedia.

The competition is open to students and trainees at any level, either as individuals or as groups; the competition closes 15 May 2020. Cash prizes and ISCB memberships will be awarded to the best contributions, as judged by a panel of experts. Awards will be presented at the ISMB 2020 conference in Montreal in July 2020.

Please share this call for entries to anyone you think may be interested. More details are available on the competition announcement page; I'm happy to answer any questions as well.

Thanks! Amkilpatrick (talk) 09:06, 6 September 2019 (UTC)

Project questions
Hi all (and especially those involved in setting up this project), a few project-related questions. It looks like there's a talk page tag for this project at, but it's not clear to me if the category system is set up. Do we plan to set up the talk page tag system like other projects have (and presumably then have a bot replace the old project tags with new ones using task force parameters like WP:MED uses, and then setup an assessments table like the old projects have)? If this is just an issue of no one having the time, let me know and I can chip away at it in the next few weeks. If this is intentional, that's fine too. Just not clear to me. Thanks all for your work on this! Ajpolino (talk) 23:11, 6 September 2019 (UTC)
 * That is the intention. I made a request at WP:Bot requests to automate the process, but it has stalled at the moment. I'm not certain who would be good to point to restart it. T.Shafee(Evo &#38; Evo)talk 00:01, 7 September 2019 (UTC)
 * Ah, I see. Thanks for the update. We were able to make the much smaller version of this work when merging WP:WATERFALLS as a taskforce into WP:RIVERS a few months ago. If you'd like a hand with this, let me know and I can try to understand what the folks at your bot request were concerned about, and reach out to some of the folks that helped out with the waterfalls move/merge. Thanks again E&E for your incredible amount of work on this! Ajpolino (talk) 02:59, 9 September 2019 (UTC)

Edit Request on ATAC-seq Page

 * Copied from WT:MOLBIO/MCB

Hi WikiProject Molecular Biology members,

I have made numerous small edits to the ATAC-seq page, a page that is within the purview of your project, to improve its quality. I've also rewritten the whole page to remove promotional and overly-technical content and to add citations and crosslinks. But I have a conflict of interest, so I cannot make the changes myself. I copied my rewrite into the talk page. Could a project member please review my rewrite and use it to replace the content that is there?

Thank you,

cglife.bmarcus (talk) 1:17, 5 September 2019 (UTC)
 * Thank you for your notice here and for being clear on your coi. I'll have a look through the suggested changes. Any other editors welcome to double-check my edits. T.Shafee(Evo &#38; Evo)talk 08:32, 9 September 2019 (UTC)

Topic Page on Origin of replication
PLOS Genetics has just published a new Topic Page. As part of this, an article was drafted, peer reviewed and published in PLOS Genetics and has now been copied over to the Origin of replication page. Comments and suggestions welcome!

Once again all refs were still using the old template over at http://topicpageswiki.plos.org as the citoid software hasn't been possible to implement there. If a wikimedia journals sister project is approved, that may solve such problems in future. I'm converting them to section-by-section (happy for assistance if anyone wants to start at the end and work backwards)! T.Shafee(Evo &#38; Evo)talk 06:07, 14 September 2019 (UTC)

Wikidata
Hello, please consider unifying your article approach, the fact is most articles about genes (human) or proteins (human) or protein families are conflations of all three. Though it is a problem in Wikidata that is solvable (instead of linking to one of the three concepts create a conflation concept in WD that links to all three WD items). Solving it consistently in WD will finally allow automatic infoboxes benefiting from all WD database imports. The first step however is that you demand such conflation concepts in Wikidata. I'm active in the molbio section of WD and would be willing to implement it for already existing articles. So please comment and take the chance.

Of course it does not solve the missing distinction protein/complex/family/complex family here but it's a start. --SCIdude (talk) 07:37, 12 October 2019 (UTC)

Practically with new articles of human genes/proteins, you would have the choice of linking to a Wikidata human gene, human protein, protein family, or conflated concept item. The infobox programmer can then see which of the 4 types the linked WD item is and display the relevant info, accordingly. --SCIdude (talk) 08:08, 12 October 2019 (UTC)


 * It's definitely a bit of a mess. I think the ideal would be to merge the articles on proteins and their genes where there are both (though I think many have already been merged) and to have clear distinctions between which sections refer to that protein/gene in humans versus sections on that protein/gene in other organisms. There are a few exge cases where a single gene can code multiple proteins, but those can probably be handled ok on wikidata with a bit of care. For gene/protein families and superfamilies there are different grouping that mostly agree (PFAM, SCOP, CATH, MEROPS, CAZY etc.) That should be the basis for articles where there is sufficient information to warrant an article (e.g. beta defensins). For multi-subunit proteins, we usually have a page for each subunit as well as the complex (e.g. 40S ribosome), but sometimes only a page for the complex as a whole. In general, for permanent complexes, having a page on the complex is probably more useful than for the subunits individually unless there's sufficient information to warrant both. Is there any wikidata way to list which pages seem to have both as a shortlist for possible manual mergers? The genetics taskforce has several mergers proposed for exactly these sorts of items. T.Shafee(Evo &#38; Evo)talk 09:48, 12 October 2019 (UTC)


 * So you say merging gene and protein would be ideal, that would mean the resp. WD item should be a conflation linking to the resp. gene and protein items. Now consider for example insulin, it's not only about gene and protein but also at least about the ortholog group, and probably also about several families from the databases you mention (which may each have their own WD item), so the WD item linked with the article should also contain these, right? Likewise with protein fragments that are handled in one article, but have all their own WD items (ideally, but I'm working on that). Likewise with complexes---almost never you write about the specific human version, but the family or ortholog group... As to your question, to see which genes with articles encode proteins with articles (or vice versa) use this query:

SELECT DISTINCT ?p ?g ?ap ?ag WHERE {  ?p wdt:P31 wd:Q8054. ?p wdt:P352 ?u. ?ap schema:about ?p. ?ap schema:isPartOf . ?p wdt:P702 ?g. ?ag schema:about ?g. ?ag schema:isPartOf . } You can see 46 pairs of this kind. I can convert this to a Wiki list, later --SCIdude (talk) 13:59, 12 October 2019 (UTC)

Here it is, maybe on its own page?
 * Aromatase Cytochrome_p450_family_19_subfamily_a_member_1
 * Apc Adenomatous_polyposis_coli
 * HAMP Hepcidin
 * Alpha-amylase AMY1C
 * Stromelysin_2 MMP10
 * NUDT15 Nudix_hydrolase_15
 * FCGR1A CD64_(biology)
 * RTL6 LDOC1L
 * FAM234A ITFG3
 * Prostaglandin_D2_receptor Prostaglandin_DP1_receptor
 * Tripartite_motif_containing_38 TRIM38
 * C19orf44 C19orf44_(gene)
 * Dentin_sialophosphoprotein_(protein) Dentin_sialophosphoprotein_(gene)
 * Granulysin GNLY
 * Myelin_proteolipid_protein Proteolipid_protein_1
 * ANK2 ANK2_(gene)
 * KCTD9 KCTD9_(gene)
 * Transmembrane_protein_44 TMEM44
 * SLAM-associated_protein SH2D1A
 * TMEM243 TMEM243_(gene)
 * Obestatin Ghrelin
 * P16 CDKN2A
 * Spermine_oxidase SMOX
 * Protein_S_(Myxococcus_xanthus) Protein_S
 * Human_serum_albumin Serum_albumin
 * Deoxyhypusine_synthase DHPS
 * Humanin MT-RNR2
 * Serine/threonine_kinase_35 STK35L1
 * Raf_kinase_inhibitor_protein Phosphatidylethanolamine_binding_protein_1
 * CCDC166 Coiled-coil_domain_containing_166
 * Glycogen_branching_enzyme 1,4-alpha-glucan_branching_enzyme_1
 * Desert_hedgehog_protein Desert_hedgehog_(protein)
 * P14arf CDKN2A
 * Cathepsin_V Cathepsin_L2
 * PPARGC1A Pparg_coactivator_1_alpha
 * NFATC2IP NFATC2IP_(gene)
 * CTRB2 Chymotrypsinogen_b2
 * Nidogen Nidogen-1
 * Gs_alpha_subunit GNAS_complex_locus
 * Transmembrane_protein_242 TMEM242
 * C9orf135 Chromosome_9_open_reading_frame_135
 * NFAM1 NFAM1_(gene)
 * C8orf58_(protein) C8orf58
 * Apolipoprotein_A2 APOA2
 * Anti-Mullerian_hormone_receptor_type_2 AMHR2_(gene)
 * DGKB Diacylglycerol_kinase_beta — Preceding unsigned comment added by SCIdude (talk • contribs) 14:13, 12 October 2019 (UTC)


 * And as example the insulin article would instead link to https://www.wikidata.org/wiki/Q70598743 --SCIdude (talk) 14:54, 12 October 2019 (UTC)

Mendelian inheritance
Please see notice at Wikipedia talk:WikiProject Molecular Biology/Genetics, which in turn relates to several recent threads at Talk:Mendelian inheritance, all initiated by at or since 11:15, 30 September 2019 (UTC). -- Red rose64 &#x1f339; (talk) 20:45, 17 October 2019 (UTC)

Topic Page on Viral quasispecies
PLOS Genetics has just published a new Topic Page. As part of this, an article was drafted, peer reviewed and published in PLOS Genetics and has now been copied over to the Viral quasispecies page. Comments and suggestions welcome!

The author over at PLOS Genetics has struggled a little to write in a fully encyclopedic style, so there are still tone elements that need updating. However, overall the content is a great expansion and improvement. T.Shafee(Evo &#38; Evo)talk 06:50, 21 October 2019 (UTC)


 * There are a bunch of "invoked but never defined" reference errors. Plantdrew (talk) 15:43, 21 October 2019 (UTC)


 * Those began to appear with by, and more appeared in subsequent edits by the same person. Looks like a wholesale copypaste from elsewhere. -- Red rose64 &#x1f339; (talk) 16:22, 21 October 2019 (UTC)


 * I think I've now fixed all the broken ref links by checking . It looks as though copying section-by-section caused some citation formatting errors for refs used more than once. The main sections of content overlap are Lethal mutagenesis and Error threshold which will need to be merged. T.Shafee(Evo &#38; Evo)talk 00:41, 22 October 2019 (UTC)

Review of mol bio info on Wikidata
A nice article on molecular biological info in Wikidata just went up on bioaRxiv: T.Shafee(Evo &#38; Evo)talk 02:34, 28 October 2019 (UTC)
 * That's pretty neat.  Seppi  333  (Insert 2¢) 21:36, 4 November 2019 (UTC)

Topic Page on Eukaryote hybrid genome
PLOS Genetics has just published a new Topic Page. As part of this, an article was drafted, peer reviewed and published in PLOS Genetics and has now been copied over to the Eukaryote hybrid genome page. The article overall has a very flat heading structure, so that might be worth multi-levelling a little. The refs are all currently using, so will have to be converted to and  over the coming days. Comments and suggestions welcome! T.Shafee(Evo &#38; Evo)talk 08:38, 28 November 2019 (UTC)

Cathelicidin
Per the HGNC entry, UniProt cathelicidin entry, and UniProt "cathelicidin family in Homo sapiens" listing, I rewrote this article and changed the wikidata sitelink to correspond to 1 gene, as the single prepropeptide is cleaved into 2 forms and there's only 1 human gene that belongs to that family. Didn't care to move stuff about a more general protein family in animals out of it.  Seppi  333  (Insert 2¢) 02:42, 30 November 2019 (UTC)

Review of Draft:Non-catalytic tyrosine-phosphorylated receptors
Hi, I am currently working on improving articles related to T cell signalling. I have noticed that the T-cell receptor activation mechanism is explained incompletely in five different articles, so I am currently adding more detailed information and trying to bring all articles together by creating main and sub-categories. I have written an article about non-catalytic tyrosine-phosphorylated receptors (Draft:Non-catalytic tyrosine-phosphorylated receptors), the receptor family that the T-cell receptor belongs to. In this article I explain the receptor triggering mechanism in more detail such that the mechanism does not have to be explained separately in many different articles. Unfortunately, the article has been waiting to be reviewed for more than 2 weeks. I would greatly appreciate it if someone could have a look at the draft and suggest some improvements. Thanks! Huhny (talk) 13:53, 4 December 2019 (UTC)
 * I'll admit that the concept seems a little obscure to me. I've seen lots of sources discussing receptors of this type but none that has discussed them as a group. Jo-Jo Eumerus (talk) 19:45, 4 December 2019 (UTC)
 * I am having a great deal of trouble parsing the title. This should be more precisely defined in the lead sentence. Boghog (talk) 21:37, 4 December 2019 (UTC)
 * Sorry, after carefully re-reading the lead, I now understand the title, but I still find it a little odd. IMHO, "Src-family kinase-dependent receptors" is less confusing. If there is no loss in accuracy, would favor changing the title to "immunoreceptor" (singular). I have made a few edits to the lead that hopefully clarifies the mechanism. Boghog (talk) 04:42, 5 December 2019 (UTC)
 * Overall, the organisation and content seems logical and the referencing looks appropriate. Although a relatively niche topic I think it's sufficiently notable, and it's clearly used in the academic literature. As others noted above, the page title might need some consideration. Are "Non-catalytic tyrosine-phosphorylated receptors", "Immunoreceptors" and "Src-family kinase-dependent receptors" strictly synonymous, or just mostly-overlapping concepts? The main source that favours the NTR name is 10.1111/imr.12008, but the other terms seem to be more common in the literature as a whole, is there another reason for favouring the NTR name that I'm missing? T.Shafee(Evo &#38; Evo)talk 01:59, 5 December 2019 (UTC)
 * Thanks for your comments. I agree, the many different names of this receptor family are confusing. I prefer the title "Non-catalytic tyrosine-phosphorylated receptors" (or "... receptor family") because "immunoreceptors" can be easily confused with the term "immune receptors" which is often broadly used for every receptor expressed by immune cells. The article 10.1111/imr.12008 also states that immunoreceptor is confusing as not all receptors of the family have immunologic functions, while Scr-family dependent receptor is restrictive as other kinases could be involved in the signalling pathway. I have changed the lead, I hope it is clearer now. Huhny (talk) 08:58, 5 December 2019 (UTC)
 * Would you mind having another look at the draft? I rearranged and rewritten the introduction, I hope it improved the understandability of the topic. Would it be possible to accept the article? Thanks Huhny (talk) 11:47, 10 December 2019 (UTC)
 * Much clearer. It might even be worth explicitly adding a History/Etymology section with the info from your comment above to explain the different names, since I suspect that might be of interest to potential readers. I'd support acceptance to mainspace. T.Shafee(Evo &#38; Evo)talk 21:07, 10 December 2019 (UTC)
 * Lead is much better and I also support moving to mainspace. Boghog (talk) 03:57, 11 December 2019 (UTC)
 * As I am fairly new to Wikipedia, I cannot move the article into mainspace. Would you mind doing this? Thanks Huhny (talk) 21:38, 12 December 2019 (UTC)

Review of Draft:Nano Cell Repair
Will someone please review this draft to verify whether it should be accepted? My guess is that it should be accepted, but I would like another opinion. Robert McClenon (talk) 18:50, 4 December 2019 (UTC)


 * It might be acceptable an article on an emerging area of nanotechnology. But the medical claims seem out of line for a technology not even in clinical trials yet. I'd want to see MEDRS sources suggesting its fitness for medical purposes. Otherwise discussion of medical applications is non-neutral speculative boosterism for the approach. -- 19:02, 4 December 2019 (UTC)
 * Defnintely notable topic and a very wide-ranging field (though definitions of scope are very variable). Although the topic overall is appropriate, I'd agree with being careful of MEDRS with the medical claims. Also, the sections "Nanorobot", "Nanocell", and "Nano neuro knitting" are merely three examples from a very wide field, so there's a risk of undue weight if they're presented as the only (or even main) developers of these sorts of tech. There are a wide range of polymer- and vesicle- based targeted drug delivery systems that come often under the umbrella of nanomedicine (inc. several in Drug_carrier page), so the "MIT are developing..." angle should probably be toned down a bit. There's quite a bit of editorialising (e.g. "Possibly the most inspiring of these prospects...", but that can be relatively easily cleaned. The link to 'dummies' seems to just go the main website page but not the specific ref. T.Shafee(Evo &#38; Evo)talk 02:17, 5 December 2019 (UTC)
 * The subject is promising, but the article needs significant revision. Is there any way that we can request more editors help us "salvage" this draft? I made edits to the lead paragraph to improve clarity. DA1312 (talk) 13:54, 13 December 2019 (UTC)

Topic Page on Nucleoid
PLOS Genetics has just published a new Topic Page. As part of this, an article was drafted, peer reviewed and published in PLOS Genetics and has now been copied over to the Nucleoid page. The article in PLOS Genetics is titled "Architecture of the Escherichia coli nucleoid" as one of the reviewers pointed out that all of the information presented was specific to E. coli. However since the previous Nucleoid article in Wikipedia almost all that is known about nucleoids comes from E. coli. My inclination is that it is still most logical to integrate the info into Nucleoid, since 1) pretty much everything that's known about nucleoids comes from E. coli and 2) the previous start-class article also only discussed E. coli so would be odd for that to be the general Wikipedia page, with separate page on "E. coli nucleoid". However I'd be interested in others' thoughts on this. Some of the figure captions are also pretty long, so could do with a significant trim. T.Shafee(Evo &#38; Evo)talk 00:27, 18 December 2019 (UTC)

Bruno Reversade’s article comments
I am asking for the advice on improving Draft:Bruno Reversade. He is a developmental biologist and human geneticist, who works as a Director of the Institute of Medical Biology at Agency for Science, Technology and Research (Singapore). Reversade is known for identifying mutated genes that cause Mendelian diseases in humans and for his research on the genetics of identical twins.

This article is a properly stated conflict of interest (COI) contribution. The reviewing editor highlighted WP:NPOV issues that I tried to resolve following advice from 2 senior editors at my talk page. Before submitting the article for the review, I would like to get a second (and professional) opinion to ensure that the issues, indeed, were resolved. Please tell what could/should be improved in the article. --Bbarmadillo (talk) 20:36, 27 December 2019 (UTC)

Fractal catalytic model - Fringe science or not?
Does anyone have any knowledge on the "Fractal catalytic model"? It's ringing Fringe science alarm bells for me. I might be flagging false positives, since I'm reading up on the 'anti-helicist' movement for this page. T.Shafee(Evo &#38; Evo)talk 10:36, 27 December 2019 (UTC) links corrected 23:20, 27 December 2019 (UTC)
 * I think you meant Fractal catalytic model, and yes, that seems fringe neuroscience, albeit from mainstream academia. The idea probably comes from the life at the edge of chaos hypothesis in the complexity/artificial life field. But I don't see any evidence that the idea has caught on in mainstream psychology or neuroscience. On the other hand, there have been lots of wild ideas proposed in the pursuit of understanding cognition, so it might be more charitably thought of as a failed mainstream model. -- 13:01, 27 December 2019 (UTC)

Adding pages to the project
Hi, I am new here. I studied molecular biology a long time ago at UC Berkeley, but never progressed to graduate school. I've always stayed interested as a lay person, and think it could be fun to work on this subject on Wikipedia, doing easy tasks, at least to begin. I thought I could begin with "adding pages to the project" by tagging them with the "Wikiproject MCB" tag. My question is, how do I find articles that have not already been tagged? Thanks, --DaringDonna (talk) 20:57, 7 January 2020 (UTC)
 * welcome! First, you’ll likely want to get the Rater tool that helps you add and modify wikiproject talk page templates much more easily than by hand.  Then you can start with this search which is all pages in  that do not have WikiProject Molecular Biology on their talk pages.  Adjust the “category depth” to dig deeper.  --Nessie (talk) 03:42, 8 January 2020 (UTC)
 * I second Nessie's welcome. Here is a slight modification of the link that they posted, that restricts the results to those that aren't tagged to Wikiproject Molecular Biology (WP:MOLBIO) or any of its daughter taskforces (e.g. WP:MCB, WP:GEN, WP:COMPBIO). Because WP:MOLBIO has several specialised taskforces, many Wikipedia articles will be tagged to one of those projects. We're also in the process of better organising so that there's always a general template on their talkpages as well as the specific taskforce. T.Shafee(Evo &#38; Evo)talk 05:51, 8 January 2020 (UTC)
 * Just tried it. Awesome! Thanks.--DaringDonna (talk) 22:57, 9 January 2020 (UTC)

Draft:CD1b
Is anyone interested in taking on this abandoned draft? I've just saved it from deletion as stale. It looks as if a bit of editing for English might make it suitable for mainspace, but I'm no expert in this area. Regards, Espresso Addict (talk) 03:51, 29 January 2020 (UTC)


 * Hi. Thanks for the heads up.  The draft was in pretty good shape, so I promoted it after a few minor edits to clean up the grammar.   Cheers.  Boghog (talk) 04:59, 29 January 2020 (UTC)

GenomeWeb
Does anyone have access to the paywalled premium content on this website?  Seppi  333  (Insert 2¢) 09:01, 29 January 2020 (UTC)

Table of human protein-coding genes
I have a technical problem that I mentioned at WT:MCB pertaining to WikiProject Molecular Biology/Molecular and Cell Biology/Human protein-coding genes1 and Human protein-coding genes2, which I am considering moving to the article space. I was wondering if anyone else had a simpler solution than the one I proposed (i.e., building a custom tool and parsing the content of thousands of gene articles).  Seppi  333  (Insert 2¢) 01:28, 5 November 2019 (UTC)
 * I'd probably check each link. Or code up a Python script that lists all the links that point to a page w/o Infobox gene if that is possible, then check each page on that list. Jo-Jo Eumerus (talk) 09:48, 5 November 2019 (UTC)
 * Not a bad idea. I'll look into coding a tool to implement both your and Boghog's suggestions.  It looks like I was right to be worried about that since M195 is one of the links in the table (granted, it's one of the withdrawn entries in the 2nd table as opposed to an approved gene symbol).  Seppi  333  (Insert 2¢) 19:33, 6 November 2019 (UTC)

Need feedback on the HGNC/UniProt external links and page sizes of the protein-coding gene lists for bot approval
See Bots/Requests_for_approval/Seppi333Bot.  Seppi  333  (Insert 2¢) 05:12, 19 December 2019 (UTC)
 * Just FYI: this bot is probably not going to be approved to automate updates to the gene lists unless others indicate they support the current layout.  Seppi  333  (Insert 2¢) 23:11, 31 December 2019 (UTC)

Articles for deletion/List of human protein-coding genes 1
I figured someone would do this sooner or later. Feel free to weigh in if you have an opinion.  Seppi  333  (Insert 2¢) 13:18, 2 January 2020 (UTC)
 * Nevermind, it's appears the outcome is going to be a unanimous keep; looking like I'll get bot approval after all.  Seppi  333  (Insert 2¢) 00:14, 16 January 2020 (UTC)

Short description standards
Spinning this topic off of this discussion, in which I proposed a help diagram for the short description help page and debated some proposed rules and changes to the contradictory and unnecessarily ambiguous help information. There's been no discussion on short descriptions in this WikiProject yet that I could find.

I'm seeing a strong need for this WikiProject to establish a standard practice for gene short descriptions, as I've been seeing how ProteinBoxBot has gone around and added "protein-coding gene in the species Homo sapiens" or some variation ("mammalian protein found in Homo sapiens", "Human gene") to every gene on Wikidata. I've been wanting to import and edit them, but based mainly on the fact no one else has touched the bot's descriptions, I didn't know if the changes I wanted to make would be acceptable. I was thinking they could do with some further disambiguating, i.e. for a notable role like BRCA1 and BRCA2 in cancer or the nature of the gene (e.g., "transcription factor", "enzyme"), which is what the help page emphasises. Also, some of ProteinBoxBot's descriptions are just wrong, like "mammalian protein found in Homo sapiens" on Histidine decarboxylase, which is found in "eukaryotes, as well as gram-negative bacteria". Another thing it's done is add "InterPro domain" to almost every protein domain, so I wanted to know if that need be included in a standard practice established for protein domains (I'd prefer not). SUM1 (talk) 07:47, 14 January 2020 (UTC)
 * I say, be bold and edit them! As you have noted, default SDs have been imposed on WP from the outside, so if you have an improvement, go ahead and override the default. This is what I do. The main use case for an SD is as an aid in mobile device searches by humans. I think SDs can be particularly helpful in this domain, as so many of our gene/protein articles have inscrutable acronyms as titles. For instance, I just boldly added "Human tumor suppressor gene" as an SD to the BRCA1 and BRCA2 articles, which I think would be an improvement upon "mammalian gene found in Homo sapiens" in mobile searches because it is a little less jargonish and gives a hint of what the gene does. If someone comes up with something even better, that is great. -- 10:10, 14 January 2020 (UTC)
 * I agree with improving from just the very generic descriptions. Is there any way to export these back out to Wikidata so that they're standardised across projects? Would editing the wikidata description achieve the same thing? T.Shafee(Evo &#38; Evo)talk 11:25, 14 January 2020 (UTC)
 * To be complete, one would have to write something like:
 * A protein [or enzyme/transcription factor/etc] coding gene found in homo sapiens and homologs in other species [where certain variations are associated with an increased risk of breast cancer].
 * Which is way longer than the 40 character suggested limit for a description. But it would at least remove the problem of having to explicitly define which phyla the gene is found in. We could sync this description with the Wikidata human gene description that through its homologene link would list the homologs. Boghog (talk) 14:05, 14 January 2020 (UTC)
 * That is a good question. One possible challenge with porting back to Wikidata is that WD is public domain, whereas WP is not. Another is that the WD backstop for short descriptions is eventually going to go away: Short_description. -- 18:53, 14 January 2020 (UTC)
 * @, : If you ask me, I would've suggested "Gene known for its role in breast cancer". That is exactly 40 characters and I believe paints the picture clearest to unfamiliar readers. If you don't mind, I'll boldly change it to that myself. SUM1 (talk) 04:31, 15 January 2020 (UTC)
 * While concise, that definition really troubles me because it implies its only role is to cause cancer. When functioning normally, it is in fact a tumor suppression gene and only certain variants in a minority of the population are associated with breast cancer. Boghog (talk) 04:51, 15 January 2020 (UTC)
 * "Human (protein/enzyme/TF)-coding gene involved in X, implicated in Y" (e.g., "protein-coding gene involved in tumor suppression, implicated in breast cancer" - 78 characters) doesn't seem like it'd be that long. Key is to be succinct. "Gene known for its role in... " is too verbose IMO.  Seppi  333  (Insert 2¢) 00:04, 16 January 2020 (UTC)
 * Addendum: I'm basing my statement of "doesn't seem like it'd be that long" off of this:Short description character limit spectrum.svg]]  Seppi  333  (Insert 2¢) 00:20, 16 January 2020 (UTC)
 * Just wanted to point out, you would in that case be basing your statement off of my perception which has had the agreement of 5 other editors so far. Which is fine; I'm glad you also agree. SUM1 (talk) 02:40, 17 January 2020 (UTC)
 * "Human" is still redundant to me. It's a thousand times more likely to exist in other mammals, vertebrates or even eukaryotes than be specific to humans. The articles mix the protein and gene together (which is logical). Only the verbose protein names are reduced to their human HUGO symbols, but the others aren't, and all of them are about the protein as well, which is usually non-specific to humans. SUM1 (talk) 03:00, 17 January 2020 (UTC)
 * "Gene known for its role in breast cancer" is not verbose on its own, only in combination with other information. It would fit within all current guidelines on short descriptions on its own. SUM1 (talk) 03:15, 17 January 2020 (UTC)
 * Then change it. Breast cancer susceptibility is in the title of the protein though. I don't believe anywhere does it suggest its only role is in cancer, especially "causing" it. It just suggests it has a role in the pathology that is breast cancer. Despite being official, I find the term "tumour suppressor" very aversive, as it usually isn't some add-on that only exists to suppress tumours but rather a core part of the cell cycle that is broken when tumours appear. Most "tumour suppressor" genes also lead to congenital developmental diseases when mutated congenitally. SUM1 (talk) 03:00, 17 January 2020 (UTC)
 * Thank you. That's all I really needed, a go-signal from other editors to start importing and editing en masse. I've already started replacing examples like "InterPro Family" with "Family of transcription factor genes" or similar. SUM1 (talk) 03:15, 17 January 2020 (UTC)
 * You're certainly welcome! Your InterPro example is a good improvement. Good luck with your editing. -- 03:37, 17 January 2020 (UTC)
 * Is there any way to simply mark a page to use the wikidata description as its short description? Effectively, in stead of importing then editing, editing on wd then cross-wiki transcluding. In most cases improving the wd description would be more useful since it's used in multiple places. It's also avoid drift between wp and wd that'd then need to be manually re-synchronised (e.g. the Gene short description). T.Shafee(Evo &#38; Evo)talk 23:03, 22 January 2020 (UTC)
 * I'm not sure if you knew, but the short description template automatically updates the Wikidata description to match. SUM1 (talk) 10:49, 23 January 2020 (UTC)
 * Ah! I didn't realise that - thank you for the info. T.Shafee(Evo &#38; Evo)talk 03:19, 24 January 2020 (UTC)
 * Just wanted to correct my explanation: the template adds a Wikidata description that matches the template's one if one doesn't exist yet. Otherwise, by default, it is set to leave the Wikidata description intact but to override it with its own description, however it can be changed in the settings to automatically update the Wikidata description with the template's one or to not touch the Wikidata description at all. All of this can be found in the gadget's settings. · • SUM1 • ·    (talk) 23:41, 3 February 2020 (UTC)

ISCB Wikipedia Competition
Hi all, a reminder that the 9th ISCB Wikipedia competition is still open for entries to improve pages relating to computational biology.

All students are welcome to enter; please spread the word and help improve this great resource! Deadline is 15 May. Thanks! Amkilpatrick (talk) 13:27, 7 February 2020 (UTC)

Kuo-Chen Chou again
There seems to be a whole group of articles on Kuo-Chen Chou and his findings that are highly promotional, hard to understand, almost exclusively reference his own papers, and have been created/expanded by a few editors whose sole editing focus seems to be this topic. I've poked around a bit, but I don't really understand the topic. Does anyone have more familiarity with the topic? Can't tell if these articles just need to be cleaned up, or if some merging/redirecting/deletion might be in order for some of these. Articles I've noticed so far: Any insight would be helpful. Thanks! Ajpolino (talk) 20:49, 21 August 2019 (UTC)
 * Kuo-Chen Chou
 * Gordon Life Science Institute (previously speedied as copyvio, just recreated which is what brought this to my attention; looks like it has been speedied again. Leaving link in case it comes back)
 * 5-step rules
 * Chou's invariance theorem
 * Pseudo K-tuple nucleotide composition
 * Pseudo amino acid composition
 * Draft:The 5-step rules for proteome or genome analysis (created but then moved to draft)
 * Wenxiang diagram
 * Low-frequency collective motion in proteins and DNA
 * Chou's distorted key theory for peptide drugs
 * My initial thoughts:
 * Kuo-Chen Chou is certainly notable and the 'recognition' section is probably fair. The 'Career' section probably needs a bit of copyediting and cleanup.
 * Sufficiently notable: PseAAC and PseKNCr are reasonably well known (though I couldn't say whether they're being over-emphasised over equivalent methods).
 * Non-notable:: More of an issue are the following likely correct but extremely niche articles and a strong over-reliance on only citing the work of Chou himself: Low-frequency collective motion in proteins and DNA (also very poorly explained), Chou's distorted key theory for peptide drugs, Chou's invariance theorem, Chou’s 5-step rule (also over-promotional).
 * On the edge: Wenxiang diagram should probably be merged with helical wheel 2-dimensional α-helical diagrams or similar.
 * T.Shafee(Evo &#38; Evo)talk 12:53, 22 August 2019 (UTC)
 * Just a note, a handful of mostly single-purpose accounts has made all of these articles. The currently active one was blocked a few hours ago for being exclusively promotional. Also thanks E&E for your thoughts above! Ajpolino (talk) 14:52, 22 August 2019 (UTC)


 * Based upon the recent Bioinformatics, Journal of Theoretical Biology and Nature editorials (e.g. "Highly cited researcher banned from journal board for citation abuse"), a careful cleanup of the material associated with Chou is in order. These, together with the Sockpuppet activities are clear cases of self-promotion. --Paul (talk) 03:54, 8 February 2020 (UTC)
 * Cripes, adds an extra layer of dubiousness to the previous info! I'll propose for deletion the ones I previously listed as non-notable now. T.Shafee(Evo &#38; Evo)talk 05:35, 9 February 2020 (UTC)
 * These articles have concerned me for a long time. There are two more that should be marked for deletion: Pseudo amino acid composition, Pseudo K-tuple nucleotide composition. Boghog (talk) 08:17, 9 February 2020 (UTC)
 * Because this guy has made it basically impossible to tell which citations to his work are legitimate and which are not, I'd be inclined to redirect most of these to Kuo-Chen Chou rather than fully deleting. But I wouldn't cry if they were nuked.  Bueller 007 (talk) 00:18, 12 February 2020 (UTC)
 * Sorry if I'm doing it wrong here -- I don't generally edit anything on Wiki but after doing a bunch of digging into this guy's Wikipedia vandalism, I felt compelled to leave a comment. If you go through his multiple accounts you find a long trail of him adding himself to quite many Wikipedia articles in a very similar spirit to his academic misconduct, and I don't think any of the mentions of his research fits where he put it. Sometimes the pages he creates are merged into other pages by other users just trying to help, making it even more of a hassle to track down what he's done. But the inclusion of him in each page that he has mentioned himself probably feels like a slap in the face to the hundreds of other researchers who worked on similar things that are being left out while he is putting himself in the spotlight. I honestly think everything he has touched is tainted and mentions of him that he included in pages throughout Wikipedia should be removed -- leaving them there benefits nobody and in fact gives a very skewed picture to anyone who comes across them. His son also seems to have created a Wikipedia article for himself although the train of destruction is much smaller, mostly just contained to him creating his own autobiography (https://en.wikipedia.org/wiki/James_J._Chou) I doubt he meets and of the "reputable" conditions either. Quasilocal (talk) 18:02, 24 February 2020 (UTC)

Template:WikiProject Molecular Biology
It looks like the 2 -imp parameters in the source code of need to be prefixed with the project title. I'm not sure what pages use this template for those projects, so I'm hesitant to change it. Once you see this, please remove the example project template from the page since it's categorizing this project page as an article.  Seppi  333  (Insert 2¢) 23:08, 31 December 2019 (UTC)

produces:
 * Never mind. I noticed the template was quite a bit more broken than this, so I fixed these parameters, the class parameter, and all the project category links.  Seppi  333  (Insert 2¢) 19:55, 3 January 2020 (UTC)
 * Thank you so much for the assistance on this! I think there's still a requirement for a bot/AWB to convert the previous templates whilst keeping current taskforce info (discussion over at WP:Bot_requests), but that's well beyond my abilities. T.Shafee(Evo &#38; Evo)talk 00:10, 5 January 2020 (UTC)
 * I've converted a few tlkpages over to to test it's listing of multiple taskforces, e.g. talk:Multiple_sequence_alignment (list). T.Shafee(Evo &#38; Evo)talk 11:05, 9 January 2020 (UTC)
 * Any issues?  Seppi  333  (Insert 2¢) 00:15, 16 January 2020 (UTC)
 * Template appears to be working exactly as hoped. Also appears to work with the rater tool. I've put in an updated bot request here that may present the automated steps required in a clearer way. T.Shafee(Evo &#38; Evo)talk 00:59, 16 January 2020 (UTC)
 * My bad, I didn't notice your reply before posting the sub-section below. There are several ways to implement the template consolidation though.  What I've described below also applies for WikiProjects Biophysics, Computational Biology, Genetics, and Gene Wiki (which I've recently added a task force since it was originally a Genetics task force and has its own WikiProject banner templates on a number of pages). Basically, all I need to know is how others would like to set this project's importance rating based upon the original task force's importance rating(s).
 * I can handle all the template conversions myself (using either template wrappers or a new bot, if necessary) as long as I know how others want it to be implemented.  Seppi  333  (Insert 2¢) 01:41, 16 January 2020 (UTC)
 * Addendum: I still need to go through and check that all of the task force's class-rating categories exist for all the acceptable class rating inputs for ; if any are missing, I need to create them. I'll do that today.  Seppi  333  (Insert 2¢) 01:48, 16 January 2020 (UTC)
 * Addendum: I still need to go through and check that all of the task force's class-rating categories exist for all the acceptable class rating inputs for ; if any are missing, I need to create them. I'll do that today.  Seppi  333  (Insert 2¢) 01:48, 16 January 2020 (UTC)

What do others think about using a bot to convert the task force templates to with task force ratings?
Following up on the section above:

I could easily code a bot or use appropriate template wrappers to convert and its template redirects (e.g., ) as follows:

Change:

to:

Is this something that others think would be useful?

If so, please state this; it would also be helpful to get feedback on how to assess the importance for the parent project in the 2nd template (see the example options listed above).

NB: I don't need to code a bot if either the original MCB importance rating or no importance rating is used as the importance rating for WikiProject Molecular Biology since all I'd need to do is use the appropriate template wrapper syntax in (as described  here). If I were to downgrade the rating by 1, I'd probably have to use a bot, although I think it might also be possible to implement this without programming a new bot via the use of a switch statement (parser function) in the wrapper template. Would need to get feedback on how to implement that if using a different importance rating is desired.

There needs to be a consensus in this thread for making this change prior to me proposing a new bot task in the event that I need to go that route.  Seppi  333  (Insert 2¢) 01:36, 16 January 2020 (UTC)


 * I'm fine with implementing the changes all of the changes that described here: Bot requests.
 * It might be better if people commented on his proposal there, keeping in mind that there are different options on how to rate an article's class/importance for this project, given the sub-project ratings.  Seppi  333  (Insert 2¢) 02:10, 16 January 2020 (UTC)
 * Support I have come upon a large number of these article throughout my edits associated with WikiProject Anatomy. Articles are often plastered with a few of these templates simultaneously, and it's clear this is the only active one of those projects. I've previously encountered situations where I wanted to bring an article or articles to a project's attention but it's very confusing without a specific venue and frustrating when there are multiple inactive venues. Additionally I often wonder about the time wasted tagging or updating articles for these wikiproject when it's clear they have a significant overlap and are inactive. It would be very useful to centralise this to a single wikiproject and I think here is a good place. I strongly support a merge into task forces here. Please ping me if there are discussions on other venues as I'd like to contribute there too. --Tom (LT) (talk) 10:49, 21 February 2020 (UTC)
 * Support for clarity! T.Shafee(Evo &#38; Evo)talk 00:00, 22 February 2020 (UTC)
 * It looks like Primefac will be taking care of this merger, per the linked discussion.  Seppi  333  (Insert 2¢) 05:59, 26 February 2020 (UTC)

Gene pages: adding links to canSAR
I'm a member of the team in the Institute of Cancer Research working on canSAR, a public knowledgebase that brings together biological, chemical, pharmacological data.

We have webpages for ~20.000 human genes, with information 3D structure, mutations, drug targets, gene-disease links, etc. We integrate and curate data from multiple sources, but additionally we also include our own druggability and gene-disease assessments as well as compound registration.

I think it would be a valuable addition to Wikipedia gene pages to have a link to a canSAR page. Ideally, a link could be added in the gene page right-hand-side panel, and generated automatically. Do you think this would be possible?

I've seen that there are bots editing automatically gene pages, so I wanted to ask whether we could collaborate to add such links. — Preceding unsigned comment added by Eloy Villasclaras (talk • contribs) 16:17, 26 February 2020 (UTC)

MNase-seq
Earlier today, an editor requested a topic expert review the relatively new article MNase-seq and suggested an expert might be found at this WikiProject. davidwr/ (talk)/(contribs)  16:02, 27 February 2020 (UTC)
 * I've taken a look through this and spot-checked a sample of the refs. All looks in order and well written and appropriately linked. Minor formatting and tone issues, but all very fixable. T.Shafee(Evo &#38; Evo)talk 09:01, 28 February 2020 (UTC)

Task forces
Congratulations on deciding to merge the closely related groups. By way of making that more successful, I offer this unsolicited advice, based almost entirely on my experience with task forces at WikiProject Medicine:


 * 1) If (some or all) the talk pages aren't getting used at all, then consider redirecting them here (say, in a few months).  In the meantime, put them all on your watchlists.
 * 2) Put some effort into tracking down both people who previously participated in the smaller groups and also people who are currently editing articles, and invite them to join you.
 * 3) * The important part isn't getting them to officially sign up. The important part is just getting them to put it on their watchlists, or at least to know that you exist.
 * 4) * I suggest starting at WikiProject Directory/Description/WikiProject Molecular Biology to find people who edit articles in this subject area.

Good luck, WhatamIdoing (talk) 19:21, 8 March 2020 (UTC)
 * Very good point. Is there an automated way to send a talkpage message to everyone on the taskforce participant lists (example)? Otherwise I'll go through and do them all manually in the coming weeks, but thought I should check for automated solution first! T.Shafee(Evo &#38; Evo)talk 10:42, 17 March 2020 (UTC)
 * A request via WP:MMS might be the best solution. It does require having the participant lists in the correct format, but I've used this in the past for sending talk page messages to WP:COMPBIO participants. Amkilpatrick (talk) 13:33, 17 March 2020 (UTC)
 * Yes, a "mass message" can do that. You might have better success with personal messages, though.  WhatamIdoing (talk) 15:31, 17 March 2020 (UTC)

About coronavirus disease outbreak
Requesting input in the page about https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 and https://en.wikipedia.org/wiki/Coronavirus_disease_2019 especially for elaborating
 * 1) 1. Three-Dimensional protein and glycoprotein structures,
 * 2) 2. Docking and infection mechanism,
 * 3) 3. Reproduction mechanism and lifecycle patern of the virus,
 * 4) 4. Host (human) molecular structures to which the virus binds or interacts.
 * 5) 5. Signaling and protein protein interactions involved with this virus.
 * 6) 6. Enzymes contained by this virus, structures of those enzymes, and the biochemical/ molecular reactions those enzymes are able to do.

Regards.

RIT RAJARSHI (talk) 16:24, 24 March 2020 (UTC)

Evaluating/Annotating structural and single-nucleotide variants
So I recently gained access to all of my brother's WGS and WES datasets and I'm considering using DeepVariant (Google's bioinformatic analysis pipeline for genomic data which utilizes a convolutional neural network for its variant caller algorithm) to analyze them as well as customizing the pipeline by running a different variant caller AI (namely, Clairvoyante) and, assuming I can hack it (pun intended), performing hybrid genome assembly with his Oxford Nanopore, PacBio, and Illumina WGS data.

Now, that's great and all since both variant caller AI can perform variant calling pretty well (i.e., I don't really need to know WTF I'm - or rather the AI I'm using is - doing for that part of the pipeline), but I have limited knowledge of and no experience whatsoever with variant annotation. I intend to apply an algorithmic approach using some python library for that, but I figure I should probably have a good idea of what's going on under the hood, so to speak. I was wondering if anyone here could point me to some resources (e.g., a comprehensive review article, online textbook, or other form of electronic media which goes deeper than SNP annotation and is not limited to just SNPs) I might be able to use as a reference for variant annotation.

The purpose of this little exercise for me isn't to identify novel variants that weren't identified at my brother's hackathon (although, if end up doing that, that'd be pretty cool); it's for me to learn human genome bioinformatics by applying pipelines to human exome and genome datasets sequenced with next-gen short-read (Illumina) and the state-of-the-art third-gen long-read sequencing technologies (PacBio SMRT & Oxford Nanopore Technologies' nanopore sequencing). For various reasons (e.g., HIPAA and the common use of NGS), this isn't something I'd learn from taking a MOOC or university course in bioinformatics, although I imagine some of it would translate to what I'm doing. My motivation for learning this is for applying it − or at least be able to do something useful − at future hackathons, which are all going to be run on Google Cloud Platform.  Seppi  333  (Insert 2¢) 08:46, 28 March 2020 (UTC)
 * Eh, seems that there aren't any active Wikipedians with a genome bioinformatics background in this project; figured there were. I guess I'll just see if I can find a comprehensive review on PubMed. I noticed Andrew Su's lab published http://sulab.org/tools/omics-pipe/ though, so I'll probably just ask him if I don't find a useful resource.  Seppi  333  (Insert 2¢) 06:03, 29 March 2020 (UTC)

Fantastic Databases and where to find them: Web applications for rushed (busy?) researchers
List of Biological Databases - Kurop1n (talk) 04:12, 16 April 2020 (UTC)
 * National Center of Biotechnology Information - NCBI
 * Omictools

ISCB Wikipedia Competition - final stretch!
Hi all, a reminder that the 9th ISCB Wikipedia competition is still open for entries to improve pages relating to computational biology. but only just: the deadline is this Friday, 15 May.

All students are welcome to enter, please spread the word! And if you see editors doing particularly good work in this area, please suggest that they enter. ISCB memberships and cash prizes for the most improved entries! Thanks, Amkilpatrick (talk) 13:14, 9 May 2020 (UTC)

Help with images in
Hi all, I noticed the old image at alpha-synuclein (File:Alfa-sinucleina.jpg) was somewhat pixelated, and unclear because the helices were on top of each other. So I made a new one in PyMOL from the same data File:Alpha-synuclein 2005.png. Imagine my surprise when I clicked the edit link at alpha-synuclein and saw only and no image link. So then I learned that apparently takes its image from wikidata, and (as far as I can tell) there's no way to override that with a locally provided image link. So then I'm off to Q14862268, where I add the newer image, and refresh the article. Now both images display in the infobox! So I remove the old one (even though it's still perfectly acceptable data for that entry I suppose), now the newer image displays as intended, but it's huge reaching down well past the lead and into the first section. So my questions: (1) Is there any way to make the displayed image smaller? (2) Can we really not override the image with a parameter at the page (e.g. this is done with the, and is often the only parameter filled out at the page)? (3) Gosh that was a pain in the butt, any way we could make this easier? At a minimum, adding some documentation to the page for folks like me who are less familiar with the wikidata system? Happy to hear anyone's thoughts. Ajpolino (talk) 14:57, 11 May 2020 (UTC)

Request for information on WP1.0 web tool
Hello and greetings from the maintainers of the WP 1.0 Bot! As you may or may not know, we are currently involved in an overhaul of the bot, in order to make it more modern and maintainable. As part of this process, we will be rewriting the web tool that is part of the project. You might have noticed this tool if you click through the links on the project assessment summary tables.

We'd like to collect information on how the current tool is used by....you! How do you yourself and the other maintainers of your project use the web tool? Which of its features do you need? How frequently do you use these features? And what features is the tool missing that would be useful to you? We have collected all of these questions at this Google form where you can leave your response. Walkerma (talk) 04:24, 27 October 2019 (UTC)

Ten simple rules for designing learning experiences that involve enhancing computational biology Wikipedia articles
This recently published article may be of interest to educators active in this WikiProject; attempting to promote a closer link between academia and Wikipedia.

--Amkilpatrick (talk) 13:13, 26 May 2020 (UTC)

DNA repair Featured article review

 * Copied here from WT:MCB - T.Shafee(Evo &#38; Evo)talk 03:13, 15 June 2020 (UTC)

I have nominated DNA repair for a featured article review here. Please join the discussion on whether this article meets featured article criteria. Articles are typically reviewed for two weeks. If substantial concerns are not addressed during the review period, the article will be moved to the Featured Article Removal Candidates list for a further period, where editors may declare "Keep" or "Delist" the article's featured status. The instructions for the review process are here. Sandy Georgia (Talk)  22:51, 14 June 2020 (UTC)
 * I'll aim to have a look through some sections. It's been a while since I did an FAR. Would definitely value the assistance of others on this! T.Shafee(Evo &#38; Evo)talk 03:13, 15 June 2020 (UTC)

Wikidata at the Bioinformatics Community Conference 2020?

 * ''Also posted at Wikidata_talk:WikiProject_Molecular_biology

What do people think about going to the community-guided conference day at the Bioinformatics Community Conference? I've drafted a suggestion for some wikidata activities in the communal conference planning document. Would others be interested in attending? Could be an ideal outreach opportunity to a community with closely aligned goals and interests. T.Shafee(evo&#38;evo) 12:06, 11 May 2020 (UTC)
 * I agree would be a great opportunity to reach out to the bioinformatics community. I'm a bit of a Wikidata newbie but would be interested in attending, happy to help out where I can! Amkilpatrick (talk) 15:30, 11 May 2020 (UTC)
 * Depending on interests, it might be good to also introduce some wikipedia items (especially since protein articles are transcluded into pfam pages). There's also a spreadsheet for indicating interest. T.Shafee(Evo &#38; Evo)talk 23:54, 11 May 2020 (UTC)
 * Hah, I kind of wish I'd known about this before it started. >.>  Seppi  333  (Insert 2¢) 16:05, 25 July 2020 (UTC)

Topic Page on Holocentric chromosome
PLOS Genetics has just published a new Topic Page. As part of this, an article was drafted, peer reviewed and published in PLOS Genetics and has now been copied over to the Holocentric chromosome page. Comments and suggestions welcome! T.Shafee(Evo &#38; Evo)talk 00:32, 31 July 2020 (UTC)

Wrong omega-numbering in many Commons images
There seems to be dozens of fatty acid images in Wikimedia Commons that have the wrong omega-numbers on the carbons. See for example
 * Fatty acid numbering.png File:Fatty acid numbering.png

The carbons from the end are "ω", "ω−1", "ω−2", etc. Here is a corrected version:
 * Fatty acid carbon numbering.svg File:Fatty acid carbon numbering.svg

This common mistake makes no difference when locating double bonds, because it happens to be compensated by another common mistake. However, it matters a lot when locating substitutions or enzyme action sites, like "an hdroxyl at position ω−1". See the description of the second image for more details. All the best, --Jorge Stolfi (talk) 04:08, 1 September 2020 (UTC)

Conformation of fatty acid and trigliceride molecules
There are uncountable instances, in Wikipedia and on the internet, of the claim "saturated and trans fatty acids are straight, while cis ones are bent". And also "saturated and trans fats have a higher melting point because, being straight, they can pack more compactly" However, I have been unable to find an authoritative source for these claims — one that is based on experimental determination of the shapes and arrangement of the molecules, rather than being just the inference of the author. A problem with that theory is that any two parts of the chain separated by a double single bond are free to rotate about it; and the energy barriers for the rotation, that come from repulsion between the H atoms on adjacent carbons, seem to be very small. Thus, one would expect that the molecules of natural fatty acids (with only a few double bonds) will be typically twisted in a random configuration, when they are in the liquid state, or in a solution, or in a complex mixture of solid triglycerides like tallow or butter. And saturated fats should be slightly more crumpled than unsaturated ones; and there should be little difference in the amount of crumpling of cis and trans acids. For the same reason the three chains of a triglyceride should usually start out in random directions, not neatly parallel. As for the differences in melting points, I can think of at least two alternative "intuitive" theoretical explanations, other than packing density. This is "Original Research", of course; but it is offered only to highlight that those claims need to be supported by experiment. Does anyone have such sources? Thanks, and all the best, --Jorge Stolfi (talk) 04:37, 1 September 2020 (UTC)
 * I don't understand "any two parts of the chain separated by a double bond are free to rotate about it" – wouldn't this imply that, for example, the cis monounsaturated oleic acid would not be in practice separable from its trans isomer, elaidic acid? Our articles report different melting points, suggesting they really are different compounds.  Though I note we report a higher density for the cis isomer, which seems to count against the idea of better packing of the trans isomer. Adrian J. Hunter(talk•contribs) 07:57, 1 September 2020 (UTC)
 * OOPS,sorry, terrible typo --I meant SINGLE bond.--Jorge Stolfi (talk) 14:27, 1 September 2020 (UTC)

10th ISCB Wikipedia Competition: entries open now!
I'm pleased to announce that entries for the 10th ISCB Wikipedia Competition are open now! The competition aims to improve Wikipedia's coverage of computational biology and bioinformatics and represents a great opportunity for students to develop their science communication skills while improving a vital public information resource. Also, cash prizes of up to $500 awarded for the best contributions! More details at the link above.

For those involved with bioinformatics or computational biology in an educational capacity, we encourage you to help your students improve relevant Wikipedia articles as a class activity - see our recent article in PLOS Computational Biology:

Please share! Happy to answer any questions also. Thanks, Amkilpatrick (talk) 12:21, 2 September 2020 (UTC)

Editing 'Structural Genomics Consortium' Wikipedia page
Dear Colleagues. I would like to add to the content of Wikipedia's Structural Genomics Consortium (SGC). The changes will be major (under the definition of Wikipedia) and thus I am writing this for advice.

The changes will include a more detailed history of the SGC including the different programs and phases from 2003 to date.

Thank you.

Sincerely, Suzanne — Preceding unsigned comment added by SZAckloo (talk • contribs) 01:28, 30 August 2020 (UTC)
 * Go for it. The Structural_Genomics_Consortium page is definitely in need of improvement. I think the current Publication overviews section would either be better integrated into the Highlight publications section or replaced with a history/milestones section that just covers the major achievements with the references themselves included inline. Does anyone know of a good exemplar page for a similar not-for-profit consortium? Some of the genome projects (e.g. HGP) might give useful ideas for additional info to include. T.Shafee(Evo &#38; Evo)talk 03:49, 30 August 2020 (UTC)
 * I have reverted your changes, which, in essentially doubling the size of the prior article, went well beyond the scope of the discussion here. Also, I believe that the changes failed to maintain the proper neutral point of view, and introduced numerous stylistic and citation errors. I would prefer to see a more extensive discussion before engaging in what amounts to a top-to-bottom rewrite of the article. WikiDan61 ChatMe!ReadMe!! 20:04, 31 August 2020 (UTC)
 * I have made some changes to the entry since we last communicated. For some of the historical information, I wondered what the community thought about using an infographic. The community's opinions are very much appreciated. (I have to admit that it is not easy to use Wikipedia. For example, I did not realize there is/was a way to continue the thread and I completely agree that I should have done so.) (SZAckloo (talk) 12:36, 1 September 2020 (UTC))
 * Infographics should be used sparingly; to keep the information accessible and searchable, information is better presented in text form. WikiDan61 ChatMe!ReadMe!! 15:41, 1 September 2020 (UTC)
 * thank you for your feedback. It has been very helpful so far. (SZAckloo (talk) 14:06, 2 September 2020 (UTC))
 * No problem. Some general editing tutorial information that might be useful can be found here. I tend to mainly use visualeditor since I find it easier, but there's advice for editing the source code as well. T.Shafee(Evo &#38; Evo)talk 11:47, 4 September 2020 (UTC)
 * thank you. I switched to 'visual editor' for references. It is quite easy to use. (SZAckloo (talk) 14:56, 8 September 2020 (UTC))

What are your thoughts about adding other Open Science initiatives linked to the SGC but that not its core activities? (SZAckloo (talk) 01:49, 11 September 2020 (UTC))

FAR for cell nucleus
I have nominated Cell nucleus for a featured article review here. Please join the discussion on whether this article meets featured article criteria. Articles are typically reviewed for two weeks. If substantial concerns are not addressed during the review period, the article will be moved to the Featured Article Removal Candidates list for a further period, where editors may declare "Keep" or "Delist" the article's featured status. The instructions for the review process are here. (t · c)  buidhe  22:17, 11 September 2020 (UTC)

Topic Page on RNA-directed DNA methylation
PLOS Genetics has just published a new Topic Page. As part of this, an article was drafted, peer reviewed and published in PLOS Genetics and has now been copied over to the RNA-directed DNA methylation page. Comments and suggestions welcome! T.Shafee(Evo &#38; Evo)talk 08:56, 9 October 2020 (UTC)

Bio/Med-tech and precision medicine startup accelerators

 * In retrospect, it does seem rather inappropriate for me to have posted what DGG deleted in this section, so I wanted to apologize to those here (re this discussion: User talk:Seppi333). My bad. I hope everyone can forgive my lack of forethought and stupidity for committing a faux pas.  Seppi  333  (Insert 2¢) 07:43, 15 October 2020 (UTC)

ExPASy
A new editor is expanding this but in the process he is introducing a promotional tone.

I have reverted the edits, but it would be useful to have a subject-matter expert dig through for anything salvageable. davidwr/ (talk)/(contribs)  21:55, 26 October 2020 (UTC)

Update to peer review page
Hi all, I've boldly updated your project's peer review page (WikiProject Molecular Biology/Molecular and Cell Biology/Peer review) by updating the instructions and archiving old reviews.

The new instructions use Wikipedia's general peer review process (WP:PR) to list peer reviews. Your project's reviews are still able to be listed on your local page too.

The benefits of this change is that review requests will get seen by a wider audience and are likely to be attended to in a more timely way (many WikiProject peer reviews remain unanswered after years). The Wikipedia peer review process is also more maintained than most WikiProjects, and this may help save time for your active members.

I've done this boldly as it seems your peer review page is pretty inactive and I am working through around 90 such similar peer review pages. Please feel free to discuss below - please ping me in your response.

Cheers and hope you are well, Tom (LT) (talk) 22:52, 12 November 2020 (UTC)
 * Thanks! I think that's a sensible solution. It's easier to go through WP:PR and post a note at this talkpage if it's relevant to the scope. T.Shafee(Evo &#38; Evo)talk 04:05, 13 November 2020 (UTC)
 * Glad to hear you think it's useful :). --Tom (LT) (talk) 10:03, 13 November 2020 (UTC)

Immune system
Immune system has been proposed to run TFA on the mainpage as the COVID vaccine is launched: please see WikiProject Medicine/Collaboration of the Month. Sandy Georgia (Talk)  17:35, 20 November 2020 (UTC)

An Edit in the Article Assay
00:21, 26 October 2020‎ 2601:985:380:afe0:575:447d:240d:24aa made a very specific addition to the introducing chapter of Assay. I think it is good will, but i do not think that it really improves the article. If the information is of encyclopedic relevance, i think it should be transferred to a more specific place. --Himbeerbläuling (talk) 12:52, 22 November 2020 (UTC)
 * Thanks, I agree it's not relevant for the general article and have reverted. Amkilpatrick (talk) 14:46, 22 November 2020 (UTC)

Should we redirect Wikipedia talk:WikiProject Molecular Biology/Molecular and Cell Biology here?
I watch both, but I'm not sure why someone would post on one rather than the other. Perhaps we discussed this in the past during the big merger, but should we just archive the rest of the contents at Wikipedia talk:WikiProject Molecular Biology/Molecular and Cell Biology and redirect that talk page here so there's just one place for folks to talk about molecular biology? Ajpolino (talk) 03:41, 13 November 2020 (UTC)
 * I support archiving and redirecting the MCB discussion page. One of the aims of this page was to move towards greater consolidation of the pages listed as taskforces so continuing that centralisation is useful. I actually think the same is true for the other WP:MOLBIO taskforce talkpages to this page and also the move new participants to in stead join this list. T.Shafee(Evo &#38; Evo)talk 06:56, 14 November 2020 (UTC)
 * ✅ For MCB.Ajpolino (talk) 17:35, 22 November 2020 (UTC)

Sample preparation (analytical chemistry) with DNA/RNA as the analyte
Anyone have a moderate-advanced working knowledge with at least some applied experience in this area? Have some questions pertaining to a protocol we've developed. Just looking for some additional feedback.

I have a sufficient understanding of this subject area to expand that article now. Will do so after we get past certain milestones sometime within the next 4-8 months.  Seppi  333  (Insert 2¢) 05:19, 26 November 2020 (UTC)


 * Just as an open question, are there any microbial taxa that are hard to lyse besides gram-positive bacteria, yeast, and spore-forming bacteria? Primarily asking in relation to protozoa and viruses.  Seppi  333  (Insert 2¢) 05:28, 26 November 2020 (UTC)

Review request for a related DYK
Hi members, I am requesting here for a DYK review of Template:Did you know nominations/Nucleoside-modified messenger RNA if anyone interested. I am posting the request regarding modRNA DYK as COVID-19 vaccine BNT162b2 has been approved for EUA in Great Britain, Bahrain whereas mRNA-1273 is also expected to get approval soon in US, Europe and both are based on Nucleoside-modified messenger RNA (modRNA) technology. The DYK can be scheduled for early weeks of December 2020 if passed. I have also notified the same at Wikipedia talk:WikiProject COVID-19. Thank you — Amkgp 💬  09:41, 9 December 2020 (UTC)
 * Also, it would be great if one can provide an image like File:MRNA-interaction.png from mRNA so that it can also be used as a lead DYK. — Amkgp 💬  09:49, 9 December 2020 (UTC)
 * I can help out with the image if I've a few examples to work from (it's pretty outside my core area). Is something like the right hand side of this diagram the sort of thing that's be useful? Most available diagrams, like this one, are just for unmodified RNA vaccines. Is the process especially different, or is the process the same? In the #Applications section, it should be made clear what the significance is of the modified nucleosides in the mRNA vaccine. Is it just stability, or do they affect its interactions? T.Shafee(Evo &#38; Evo)talk 22:29, 9 December 2020 (UTC)
 * I think right hand side of this diagram would be useful. Actually, I do not have medical or molecular biology background (I am from engineering background with interests in medical application) so I cannot comment anything about Is the process especially different, or is the process the same? OR stability, or do they affect its interactions. I took help and suggestions from an expert (see here) and added File:Ribosome mRNA translation en.svg in the article modRNA and in the Template:Did you know nominations/Nucleoside-modified messenger RNA. I was looking for an image which can show how modRNA is used for the new COVID-19 vaccines and Tissue regeneration. — Amkgp 💬  17:40, 10 December 2020 (UTC)
 * no worries! I'll make a version of the mature review figure]. I'll see about updating File:Ribosome mRNA translation en.svg whilst I'm at it. T.Shafee(Evo &#38; Evo)talk 22:36, 10 December 2020 (UTC)

Enzyme inhibitor
Enzyme inhibitor has turned into quite a wreck since Tim Vickers stopped editing; unless someone is able to bring it to WP:WIAFA standard (and fix the image layout mess, too), the article should be submitted to WP:Featured article review. It was last reviewed in 2006, and is the oldest article from this Project at Unreviewed featured articles/2020. Please place notes for article improvements needed at Talk:Enzyme inhibitor. Sandy Georgia (Talk)  20:56, 13 December 2020 (UTC)

Enzyme kinetics
Similar for Talk:Enzyme kinetics Sandy Georgia (Talk)  21:04, 13 December 2020 (UTC)

eIF2α, EIF2S1, & Integrated stress response#eIF2α
With on ISRIB, I saw that someone had converted the eIF2α redlink (as of 2020-12-29T01:42:45) to eIF2α. I thought that I would create a eIF2α redirect to EIF2S1, but when I searched on eIF2α, I noticed Integrated stress response among the results.

Two things I think:


 * There is currently no relationship between EIF2S1 & Integrated stress response, & that there should be.


 * There should be a redirect for eIF2α.

This is not my area of expertise, hence the reason I bring this here. I am hoping someone with more knowledge than I have about eIF2α, EIF2S1, & integrated stress response will infer the correct solution. Peaceray (talk) 22:00, 29 December 2020 (UTC)
 * Thanks ! You're right, eIF2α should redirect to eIF2S1 (and the same for beta and gamma). I created the redirects, linked the ISR article from eIF2S1, and cleaned up the ISR article a bit. Opabinia regalis (talk) 23:35, 3 January 2021 (UTC)

Sandbox organiser
Hi all

I've been working on a tool for the past few months that you may find useful. Sandbox organiser is a set of tools to help you better organise your draft articles and other pages in your userspace. It also includes areas to keep your to do lists, bookmarks, list of tools. You can customise your sandbox organiser to add new features and sections. Once created you can access it simply by clicking the sandbox link at the top of the page. You can create and then customise your own sandbox organiser just by clicking the button on the page. All ideas for improvements and other versions would be really appreciated.

Huge thanks to PrimeHunter and NavinoEvans for their work on the technical parts, without them it wouldn't have happened.

John Cummings (talk) 11:09, 6 February 2021 (UTC)

10th ISCB Wikipedia Competition
Dear all, a reminder that entries for the 10th ISCB Wikipedia Competition are still open (deadline 14th May). The competition aims to improve Wikipedia's coverage of computational biology and bioinformatics and represents a great opportunity for students to develop their science communication skills while improving a vital public information resource. Also, cash prizes of up to $500 awarded for the best contributions! More details at the link above.

For those involved with bioinformatics or computational biology in an educational capacity: please share this link with your students! We also encourage educators to help students improve relevant Wikipedia articles as a class activity - see our recent article in PLOS Computational Biology:

Please share! Happy to answer any questions also. Thanks, Amkilpatrick (talk) 12:28, 16 February 2021 (UTC)

Neoblast
Neoblast is being reviewed as a GA. Can someone point me to the criteria in this project for formating a Molecular Biology article? Thank you. --Akrasia25 (talk) 13:49, 18 February 2021 (UTC)
 * Hi, if such a guideline exists, it's mentioned rarely enough that I've never heard of it (a quick search turns up WikiProject_Molecular_Biology/Style_guide_(gene_and_protein_articles) for gene/protein articles, but nothing that would fit neoblast). If you're looking for inspiration for how to improve that article, I might suggest looking to other current GAs and FAs to see how they look. I just noticed the categorization system for this project isn't working as intended, with only six articles in Category:GA-Class Molecular Biology articles, but you can still see a list of GAs and FAs from the former iterations of this project here for WikiProject Genetics and here for Molecular and Cell Biology. For either use the drop-down menu at the top-left to select "GA" or "FA".
 * Part of the problem you'll no doubt find is that relatively few editors are currently around who work on molecular biology articles. So you may find that many of the GAs/FAs were reviewed and promoted in the distant past. That said, there are still a few of us here. So if there's any way we can help, please do reach out. All the best, Ajpolino (talk) 01:34, 19 February 2021 (UTC)

Solution to annoying Wikidata problem in sight
The problem that Wikipedia articles cover multiple Wikidata concepts will get a solution with the possibility to associate Wikidata concepts with Wikipedia Redirect pages. This is in the process of implementation right now.

Maybe you want to think already about how to use this. Obviously, articles covering gene + protein + protein family would ideally have separate paragraphs for each of these, and redirect pages linking to these sections. --SCIdude (talk) 10:47, 19 February 2021 (UTC)