1999 Texas Southern Tigers football team

The 1999 Texas Southern Tigers football team represented Texas Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 1999 NCAA Division I-AA football season. Led by sixth-year head coach William A. Thomas, the Tigers compiled an overall record of 6–5, with a mark of 3–1 in conference play, and finished second in the West Division of the SWAC.