2010 Texas Southern Tigers football team

The 2010 Texas Southern Tigers football team represented Texas Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 2010 NCAA Division I FCS football season. Led by third-year head coach Johnnie Cole, the Tigers compiled an overall record of 9–3, with a mark of 8–1 in conference play, and finished as SWAC champion.

In October 2012, the NCAA officially vacated all wins from the 2010 season as part of their penalties for playing ineligible players during the season. This resulted in the vacating of all nine victories and their SWAC championship.