2001 Texas Southern Tigers football team

The 2001 Texas Southern Tigers football team represented Texas Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 2001 NCAA Division I-AA football season. Led by eighth-year head coach William A. Thomas, the Tigers compiled an overall record of 4–6, with a mark of 3–4 in conference play, and finished tied for third in the West Division of the SWAC.