2000 United States Senate election in Mississippi

The 2000 United States Senate election in Mississippi was held on November 7, 2000. Incumbent Republican U.S. Senator Trent Lott won re-election to a third term.

Democratic

 * Troy Brown, perennial candidate

Republican

 * Trent Lott, incumbent U.S. Senator first elected in 1988

Counties that flipped from Republican to Democratic

 * Quitman (Largest city: Lambert)
 * Sharkey (Largest city: Rolling Fork)
 * Issaquena (Largest city: Mayersville)
 * Marshall (Largest city: Holly Springs)
 * Noxubee (Largest city: Macon)
 * Bolivar (Largest city: Cleveland)
 * Sunflower (Largest city: Indianola)
 * LeFlore (Largest city: Greenwood)