2013 U.S. National Indoor Tennis Championships – Women's singles

Sofia Arvidsson was the defending champion, but lost to Marina Erakovic in the second round in a replay of the previous final. Erakovic made it to the finals again, this year defeating Sabine Lisicki 6–1 in the first set after Lisicki retired due to illness before the start of the second set.

Seeds
• # 🇧🇪 Kirsten Flipkens (quarterfinals)

• # 🇸🇪 Sofia Arvidsson (second round)

• # 🇩🇪 Sabine Lisicki (final, retired due to illness)

• # 🇬🇧 Heather Watson (quarterfinals)

• # 🇨🇿 Lucie Hradecká (first round)

• # Chanelle Scheepers (first round)

• # 🇸🇰 Magdaléna Rybáriková (semifinals)

• # 🇫🇷 Kristina Mladenovic (quarterfinals)

Seeds
• # 🇺🇸 Madison Keys (qualified)

• # 🇷🇸 Vesna Dolonc (first round, retired)

• # 🇸🇰 Jana Čepelová (qualified)

• # Monica Puig (first round)

• # Mirjana Lučić-Baroni (qualifying competition)

• # 🇺🇸 Maria Sanchez (qualified)

• # 🇷🇺 Valeria Savinykh (first round)

• # 🇺🇸 Alexa Glatch (qualifying competition)

Qualifiers
• # 🇺🇸 Madison Keys

• # 🇺🇸 Maria Sanchez

• # 🇸🇰 Jana Čepelová

• # 🇫🇷 Claire Feuerstein