2013 Western & Southern Open – Women's singles

Victoria Azarenka defeated Serena Williams in the final, 2–6, 6–2, 7–6(8–6) to win the women's singles tennis title at the 2013 Cincinnati Masters. It was Azarenka's second win against Williams during the year, and Williams' fourth and last loss of the year.

Li Na was the defending champion, but lost to Williams in the semifinals.

This marked the final professional appearance of reigning Wimbledon champion Marion Bartoli; she lost to Simona Halep in the second round.

Seeds
The top eight seeds received a bye into the second round. • # 🇺🇸 Serena Williams (final)

• # 🇧🇾 Victoria Azarenka (champion)

• # 🇷🇺 Maria Sharapova (second round)

• # 🇵🇱 Agnieszka Radwańska (quarterfinals, withdrew because of personal reasons)

• # 🇨🇳 Li Na (semifinals)

• # 🇮🇹 Sara Errani (third round)

• # 🇨🇿 Petra Kvitová (third round)

• # 🇫🇷 Marion Bartoli (second round)

• # 🇩🇪 Angelique Kerber (third round)

• # Caroline Wozniacki (quarterfinals)

• # 🇦🇺 Samantha Stosur (third round)

• # 🇮🇹 Roberta Vinci (quarterfinals)

• # 🇧🇪 Kirsten Flipkens (first round)

• # 🇷🇸 Jelena Janković (semifinals)

• # 🇷🇸 Ana Ivanovic (first round)

• # 🇷🇺 Maria Kirilenko (second round)

Seeds
• # 🇵🇱 Urszula Radwańska (first round)

• # 🇺🇸 Madison Keys (withdrew because of a right shoulder injury)

• # 🇷🇴 Monica Niculescu (qualifying competition, lucky loser)

• # 🇩🇪 Annika Beck (qualified)

• # Stefanie Vögele (first round)

• # 🇩🇪 Andrea Petkovic (qualified)

• # Monica Puig (qualified)

• # 🇯🇵 Ayumi Morita (first round)

• # 🇪🇸 Lourdes Domínguez Lino (qualifying competition)

• # 🇨🇳 Zheng Jie (first round)

• # 🇮🇹 Francesca Schiavone (first round)

• # 🇮🇹 Karin Knapp (qualified)

• # 🇨🇦 Eugenie Bouchard (qualified)

• # 🇯🇵 Kimiko Date-Krumm (qualifying competition)

• # Donna Vekić (first round)

• # 🇧🇬 Tsvetana Pironkova (first round)

• # Chanelle Scheepers (qualifying competition)

• # 🇸🇪 Johanna Larsson (qualifying competition)

• # 🇪🇸 Sílvia Soler Espinosa (first round)

• # 🇦🇷 Paula Ormaechea (first round)

• # 🇨🇿 Karolína Plíšková (qualifying competition)

• # 🇷🇴 Irina-Camelia Begu (first round)

• # 🇧🇾 Olga Govortsova (qualifying competition)

• # 🇳🇿 Marina Erakovic (qualified)

Qualifiers
• # Petra Martić

• # 🇨🇦 Eugenie Bouchard

• # 🇺🇸 Vania King

• # 🇩🇪 Annika Beck

• # 🇸🇪 Sofia Arvidsson

• # 🇩🇪 Andrea Petkovic

• # Monica Puig

• # 🇸🇰 Jana Čepelová

• # Polona Hercog

• # Anna Tatishvili

• # 🇳🇿 Marina Erakovic

• # 🇮🇹 Karin Knapp

Lucky loser

 * 1) 🇷🇴 Monica Niculescu