2013 Mutua Madrid Open – Women's singles

Defending champion Serena Williams defeated Maria Sharapova in the final, 6–1, 6–4 to win the women's singles tennis title at the 2013 Madrid Open.

Seeds
• # 🇺🇸 Serena Williams (champion)

• # 🇷🇺 Maria Sharapova (final)

• # 🇧🇾 Victoria Azarenka (second round)

• # 🇵🇱 Agnieszka Radwańska (second round)

• # 🇨🇳 Li Na (first round)

• # 🇩🇪 Angelique Kerber (quarterfinals)

• # 🇮🇹 Sara Errani (semifinals)

• # 🇨🇿 Petra Kvitová (second round)

• # 🇦🇺 Samantha Stosur (first round)

• # Caroline Wozniacki (first round)

• # 🇷🇺 Nadia Petrova (second round)

• # 🇮🇹 Roberta Vinci (first round)

• # 🇷🇺 Maria Kirilenko (third round)

• # 🇫🇷 Marion Bartoli (third round)

• # 🇸🇰 Dominika Cibulková (second round)

• # 🇷🇸 Ana Ivanovic (semifinals)

Seeds
• # 🇷🇴 Monica Niculescu (first round)

• # 🇺🇸 Christina McHale (qualified)

• # Stefanie Vögele (qualifying competition, lucky loser)

• # 🇨🇿 Lucie Hradecká (first round)

• # 🇩🇪 Annika Beck (first round)

• # Chanelle Scheepers (qualified)

• # 🇧🇾 Olga Govortsova (first round)

• # 🇺🇸 Madison Keys (qualifying competition, lucky loser)

• # 🇸🇪 Johanna Larsson (qualifying competition)

• # 🇺🇸 Lauren Davis (first round)

• # Anna Tatishvili (first round)

• # 🇳🇿 Marina Erakovic (first round)

• # 🇺🇦 Lesia Tsurenko (qualified)

• # 🇺🇸 Bethanie Mattek-Sands (qualified)

• # 🇺🇸 Jamie Hampton (first round)

• # 🇨🇿 Karolína Plíšková (first round)

Qualifiers
• # 🇪🇸 María Teresa Torró Flor

• # 🇺🇸 Christina McHale

• # 🇺🇦 Lesia Tsurenko

• # 🇰🇿 Yulia Putintseva

• # 🇷🇴 Alexandra Dulgheru

• # Chanelle Scheepers

• # 🇮🇹 Camila Giorgi

• # 🇺🇸 Bethanie Mattek-Sands

Lucky losers
• # Stefanie Vögele

• # 🇺🇸 Madison Keys