2021–22 R.S.C. Anderlecht season

The 2021–22 season was the 114th season in the existence of R.S.C. Anderlecht and the club's 86th consecutive season in the top flight of Belgian football. In addition to the domestic league, Anderlecht participated in this season's edition of the Belgian Cup and the UEFA Europa Conference League.

Matches
The league fixtures were announced on 8 June 2021.

Belgian Cup
Anderlecht entered the competition in the sixth round. They were drawn away to RAAL La Louvière in the sixth round and Seraing in the seventh round.

Third qualifying round
The draw for the third qualifying round was held on 19 July 2021.

Play-off round
The draw for the play-off round was held on 2 August 2021.

Appearances and goals

 * Source:
 * Numbers in parentheses denote appearances as substitute.
 * Players with names struck through and marked † left the club during the playing season.
 * Players with names in italics and marked * were on loan from another club for the whole of their season with Anderlecht.
 * Players listed with no appearances have been in the matchday squad but only as unused substitutes.
 * Key to positions: GK – Goalkeeper; DF – Defender; MF – Midfielder; FW – Forward

Squad appearances and goals

 * Last updated 30 November 2021

! colspan=14 style=background:#dcdcdc; text-align:center|Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center|Defenders

! colspan=14 style=background:#dcdcdc; text-align:center|Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center|Forwards

! colspan=14 style=background:#dcdcdc; text-align:center|Players who have made an appearance this season but have left the club


 * }