2015 French Open – Men's singles

Stan Wawrinka defeated Novak Djokovic in the final, 4–6, 6–4, 6–3, 6–4 to win the men's singles tennis title at the 2015 French Open. It was his first French Open title, and second major title overall. As he did when he won the 2014 Australian Open, Wawrinka defeated the world No. 1 and world No. 2 en route to the title. Djokovic was attempting to complete the career Grand Slam. The final was the only major match Djokovic lost in 2015, thus preventing him from completing the Grand Slam.

Rafael Nadal was the five-time defending champion, but lost to Djokovic in the quarterfinals. This was only Nadal's second career defeat at the French Open (the previous one being in 2009 to Robin Söderling) and ended his record win streak at the tournament of 39 matches. Nadal had won all six of his prior matches against Djokovic at the French Open. Nadal fell to world No. 10 in the rankings after the loss, his lowest position since April 18, 2005.

Roger Federer was attempting to become the first male player in the Open Era to achieve the double career Grand Slam, but lost to Wawrinka in the quarterfinals.

Seeds
• 🇷🇸 Novak Djokovic (final)

• Roger Federer (quarterfinals)

• 🇬🇧 Andy Murray (semifinals)

• 🇨🇿 Tomáš Berdych (fourth round)

• 🇯🇵 Kei Nishikori (quarterfinals)

• 🇪🇸 Rafael Nadal (quarterfinals)

• 🇪🇸 David Ferrer (quarterfinals)

•  Stan Wawrinka (champion)

•  Marin Čilić (fourth round)

• 🇧🇬 Grigor Dimitrov (first round)

• 🇪🇸 Feliciano López (first round)

• 🇫🇷 Gilles Simon (fourth round)

• 🇫🇷 Gaël Monfils (fourth round)

• 🇫🇷 Jo-Wilfried Tsonga (semifinals)

•  Kevin Anderson (third round)

• 🇺🇸 John Isner (second round)

• 🇧🇪 David Goffin (third round)

• 🇪🇸 Tommy Robredo (second round)

• 🇪🇸 Roberto Bautista Agut (second round)

• 🇫🇷 Richard Gasquet (fourth round)

•  Pablo Cuevas (third round)

• 🇩🇪 Philipp Kohlschreiber (second round)

• 🇦🇷 Leonardo Mayer (third round)

•  Ernests Gulbis (second round)

•  Ivo Karlović (first round)

• 🇪🇸 Guillermo García-López (first round)

• 🇦🇺 Bernard Tomic (second round)

• 🇮🇹 Fabio Fognini (second round)

• 🇦🇺 Nick Kyrgios (third round)

• 🇫🇷 Adrian Mannarino (first round)

• 🇷🇸 Viktor Troicki (second round)

• 🇪🇸 Fernando Verdasco (second round)