2012 Western & Southern Open – Women's singles

Li Na defeated Angelique Kerber in the final, 1–6, 6–3, 6–1 to win the women's singles tennis title at the 2012 Cincinnati Masters.

Maria Sharapova was the reigning champion, but withdrew because of a stomach virus.

Seeds
The top eight seeds and the Montreal finalists receive a bye into the second round. • # 🇵🇱 Agnieszka Radwańska (quarterfinals)

• # 🇺🇸 Serena Williams (quarterfinals)

• # 🇦🇺 Samantha Stosur (quarterfinals)

• # 🇨🇿 Petra Kvitová (semifinals)

• # 🇩🇪 Angelique Kerber (final)

• # Caroline Wozniacki (third round)

• # 🇮🇹 Sara Errani (third round)

• # 🇫🇷 Marion Bartoli (second round)

• # 🇨🇳 Li Na (champion)

• # 🇷🇸 Ana Ivanovic (withdrew because of a right foot injury)

• # 🇸🇰 Dominika Cibulková (second round, retired)

• # 🇷🇺 Maria Kirilenko (first round)

• # 🇷🇸 Jelena Janković (first round)

• # 🇮🇹 Francesca Schiavone (first round)

• # 🇷🇺 Nadia Petrova (first round, retired because of dizziness)

• # 🇨🇿 Lucie Šafářová (first round)

• # 🇷🇺 Anastasia Pavlyuchenkova (quarterfinals)

Seeds
• # 🇰🇿 Yaroslava Shvedova (qualified)

• # 🇵🇱 Urszula Radwańska (qualified)

• # 🇺🇸 Vania King (qualified)

• # 🇰🇿 Galina Voskoboeva (withdrew)

• # 🇨🇿 Iveta Benešová (first round)

• # 🇪🇸 Sílvia Soler Espinosa (first round)

• # Arantxa Rus (first round)

• # 🇭🇺 Tímea Babos (qualifying competition, lucky loser)

• # 🇨🇿 Lucie Hradecká (first round)

• # 🇷🇸 Bojana Jovanovski (first round)

• # 🇺🇸 CoCo Vandeweghe (first round)

• # 🇪🇸 Lourdes Domínguez Lino (first round)

• # 🇬🇧 Anne Keothavong (first round)

• # Anna Tatishvili (qualifying competition, lucky loser)

• # Kiki Bertens (qualified)

• # 🇧🇾 Olga Govortsova (qualifying competition)

• # 🇷🇴 Irina-Camelia Begu (qualifying competition)

• # 🇭🇺 Melinda Czink (qualifying competition)

• # 🇬🇧 Laura Robson (qualifying competition)

• # 🇨🇿 Andrea Hlaváčková (qualified)

• # 🇫🇷 Pauline Parmentier (first round)

• # 🇸🇪 Johanna Larsson (qualified)

• # 🇺🇦 Kateryna Bondarenko (qualifying competition)

• # 🇪🇸 Garbiñe Muguruza (first round)

Qualifiers
• # 🇰🇿 Yaroslava Shvedova

• # 🇵🇱 Urszula Radwańska

• # 🇺🇸 Vania King

• # 🇺🇿 Akgul Amanmuradova

• # 🇸🇪 Johanna Larsson

• # Kiki Bertens

• # 🇰🇿 Sesil Karatantcheva

• # 🇺🇸 Madison Keys

• # 🇦🇺 Casey Dellacqua

• # 🇨🇿 Andrea Hlaváčková

• # Eleni Daniilidou

• # 🇺🇸 Bethanie Mattek-Sands

Lucky losers

 * 1) 🇭🇺 Tímea Babos
 * 2)  Anna Tatishvili