2021–22 Fortuna Düsseldorf season

The 2021–22 season is Fortuna Düsseldorf's 127th season in existence and the club's second season back in the 2. Bundesliga, the second tier of German football, following their relegation from the Bundesliga in the 2019–20 season. The club also participated in the DFB-Pokal.

Background and pre-season
Fortuna Düsseldorf finished the 2020–21 season in 5th place, 8 points below the automatic promotion places and 6 points below the promotion play-off place. Manager Uwe Rösler's contract was not renewed at the end of the previous season. Christian Preußer was appointed as manager in May 2021.

Season summary
Preußer was sacked as manager on 8 February 2022, and replaced by Daniel Thioune. Düsseldorf finished the season in 10th.