2021–22 RB Leipzig season

The 2021–22 season was the 13th season in the existence of RB Leipzig and the club's sixth consecutive season in the top flight of German football. In addition to the domestic league, RB Leipzig participated in this season's editions of the DFB-Pokal, the UEFA Champions League and the UEFA Europa League. This was Jesse Marsch's first season as coach, succeeding Julian Nagelsmann before being sacked mid-season.

Matches
The league fixtures were announced on 25 June 2021.

Group stage
The draw for the group stage was held on 26 August 2021.

Knockout round play-offs
The draw for the knockout round play-offs was held on 13 December 2021. 

Round of 16
The draw for the round of 16 was held on 25 February 2022. After being drawn against Russian side Spartak Moscow, Leipzig received a bye to the next round following Spartak's expulsion by UEFA and FIFA due to the Russian invasion of Ukraine.

Quarter-finals
The draw for the quarter-finals was held on 18 March 2022.

Semi-finals
The draw for the semi-finals was held on 18 March 2022, after the quarter-final draw.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season